Quantitative structure-activity relationship studies for potential rho-associated protein kinase inhibitors

Gajo, Giovanna Cardoso; Assis, Tamiris Maria de; Assis, Letícia Cristina; Ramalho, Teodorico Castro; Cunha, Elaine Fontes Ferreira da

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Campo DC	Valor	Idioma
dc.creator	Gajo, Giovanna Cardoso	-
dc.creator	Assis, Tamiris Maria de	-
dc.creator	Assis, Letícia Cristina	-
dc.creator	Ramalho, Teodorico Castro	-
dc.creator	Cunha, Elaine Fontes Ferreira da	-
dc.date.accessioned	2018-09-15T12:37:11Z	-
dc.date.available	2018-09-15T12:37:11Z	-
dc.date.issued	2016	-
dc.identifier.citation	GAJO, G. C. et al. Quantitative structure-activity relationship studies for potential rho-associated protein kinase inhibitors. Journal of Chemistry, [S.l.], [2016?].	pt_BR
dc.identifier.uri	http://repositorio.ufla.br/jspui/handle/1/30446	-
dc.description.abstract	A series of pyridylthiazole derivatives developed by Lawrence et al. as Rho-associated protein kinase inhibitors were subjected to four-dimensional quantitative structure-activity relationship (4D-QSAR) analysis. The models were generated applying genetic algorithm (GA) optimization combined with partial least squares (PLS) regression. The best model presented validation values of , , , , , , and . Furthermore, analyzing the descriptors it was possible to propose new compounds that predicted higher inhibitory concentration values than the most active compound of the series.	pt_BR
dc.language	pt_BR	pt_BR
dc.publisher	Hindawi	pt_BR
dc.rights	Attribution 4.0 International	*
dc.rights	acesso aberto	pt_BR
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.source	Journal of Chemistry	pt_BR
dc.title	Quantitative structure-activity relationship studies for potential rho-associated protein kinase inhibitors	pt_BR
dc.type	Artigo	pt_BR
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