Efeito do mananoligossacarídeo (MOS) sobre desempenho, saúde intestinal e resposta imune em leitões pós-desmame desafiados por Escherichia coli

Abstract

Piglets in postweaning are susceptible to performance declines, intestinal health and immunity due to physiological changes occurring during this breeding phase, concomitant with the occurrence of pathogenic Escherichia coli infections. In order to minimize the direct and indirect losses caused by this sum of factors, the prebiotic mananoligosaccharide (MOS), from yeast cell wall, is used. The objective of this study was to analyze the performance, intestinal health and immune response of piglets in postweaning in a completely randomized experimental design, with and without inclusion of 0.1% commercial MOS (HyperGen®, Biorigin) in the diet and with and without inoculation via oral Escherichia coli K88 + enterotoxigenic. In the microbiological culture there was growth of E. coli in all treatments, the negative control treatment (DC-INO) showed the lowest growth and the treatments with challenge (DC + INO and MOS + INO) showed the highest growth, showing that inoculation was effective due to the greater proliferation of E. coli in the gut of the inoculated animals, as well as a higher formation of volatile fatty acids (VFA) in these animals due to possible dysbiosis caused by the pathogen. Animals that received MOS, regardless of health challenge (MOS + INO and MOS-INO), had higher numbers of proliferating cells in the lymphoid tissues of ileum and mesenteric lymph node, with larger intestinal villi, and better performance indices compared to treatment negative control DC-INO. This proves that the inclusion of MOS in the concentration of 0.1% was able to modulate the immune system, mainly against sanitary challenge, in a controlled and effective way, contributing to the final results of performance. The action of E. coli caused an imbalance of the intestinal microbiota, but did not impair the performance of animals treated with MOS. The treatment with MOS + INO obtained more gains and better performance, due to the action of MOS under intestinal health and the contribution of the VFA, produced in greater quantity due to dysbiosis, that even being a malefic alteration, it increased the energy source of enterocytes, which increased the size of the villi, which contributed to the final gains.