Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/33071
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dc.creatorBernardes, Nathalia-
dc.creatorDias, Danielle da Silva-
dc.creatorStoyell-Conti, Filipe Fernandes-
dc.creatorBrito-Monzani, Janaina de Oliveira-
dc.creatorMalfitano, Christiane-
dc.creatorCaldini, Elia Garcia-
dc.creatorUlloa, Luis-
dc.creatorLlesuy, Susana Francisca-
dc.creatorIrigoyen, Maria-Cláudia-
dc.creatorAngelis, Kátia de-
dc.date.accessioned2019-02-27T10:38:30Z-
dc.date.available2019-02-27T10:38:30Z-
dc.date.issued2018-
dc.identifier.citationBERNARDES, N. et al. Baroreflex impairment precedes cardiometabolic dysfunction in an experimental model of metabolic syndrome: role of inflammation and oxidative stress. Scientific Reports, [S. l.], v. 8, p. 1-10, 2018. doi: 10.1038/s41598-018-26816-4.pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/33071-
dc.description.abstractThis study analyzes whether autonomic dysfunction precedes cardiometabolic alterations in spontaneously hypertensive rats (SHR) with fructose overload. Animals were randomly distributed into three groups: control, hypertensive and hypertensive with fructose overload. Fructose overload (100 g/L) was initiated at 30 days old, and the animals (n = 6/group/time) were evaluated after 7, 15, 30 and 60 days of fructose consumption. Fructose consumption reduced baroreflex sensitivity by day 7, and still induced a progressive reduction in baroreflex sensitivity over the time. Fructose consumption also increased TNFα and IL-6 levels in the adipose tissue and IL-1β levels in the spleen at days 15 and 30. Fructose consumption also reduced plasmatic nitrites (day 15 and 30) and superoxide dismutase activity (day 15 and 60), but increased hydrogen peroxide (day 30 and 60), lipid peroxidation and protein oxidation (day 60). Fructose consumption increased arterial pressure at day 30 (8%) and 60 (11%). Fructose consumption also induced a late insulin resistance at day 60, but did not affect glucose levels. In conclusion, the results show that baroreflex sensitivity impairment precedes inflammatory and oxidative stress disorders, probably by inducing hemodynamic and metabolic dysfunctions observed in metabolic syndrome.pt_BR
dc.languageen_USpt_BR
dc.publisherNaturept_BR
dc.rightsacesso abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourceScientific Reportspt_BR
dc.subjectSpontaneously hypertensive ratspt_BR
dc.subjectBaroreflexpt_BR
dc.subjectMetabolic syndromept_BR
dc.subjectRatos espontaneamente hipertensospt_BR
dc.subjectBarorreflexopt_BR
dc.subjectSíndrome metabólicapt_BR
dc.titleBaroreflex impairment precedes cardiometabolic dysfunction in an experimental model of metabolic syndrome: role of inflammation and oxidative stresspt_BR
dc.typeArtigopt_BR
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