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dc.creatorFerreira-Silva, M. M.-
dc.creatorTeixeira, L. A. S.-
dc.creatorTibúrcio, M. S.-
dc.creatorPereira, G. A.-
dc.creatorRodrigues, V.-
dc.creatorPalis, M.-
dc.creatorAfonso, P.-
dc.creatorAlves, M.-
dc.creatorFeitosa, J. M.-
dc.creatorUrias, E.-
dc.creatorSantos, E. M.-
dc.creatorCarvalho, S. F. G.-
dc.creatorMoraes-Souza, H.-
dc.date.accessioned2019-06-04T16:24:37Z-
dc.date.available2019-06-04T16:24:37Z-
dc.date.issued2018-12-
dc.identifier.citationFERREIRA-SILVA, M. M. et al. Socio‐epidemiological characterisation of blood donors with asymptomatic Leishmania infantum infection from three Brazilian endemic regions and analysis of the transfusional transmission risk of visceral leishmaniasis. Transfusion Medicine, [S.l.], v. 28, n. 6, p. 433-439, Dec. 2018.pt_BR
dc.identifier.urihttps://www.onlinelibrary.wiley.com/doi/full/10.1111/tme.12553pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/34609-
dc.description.abstractObjectives This study assessed the prevalence of visceral leishmaniasis in blood donors from three endemic regions in Brazil and evaluated the risk of transmission by transfusion. Background Despite strong evidence of the transmission of visceral leishmaniasis through blood transfusion, the real risk, an essential condition for taking effective measures to control this serious disease, has not been determined. Methods A multicentre study was performed in highly endemic areas. Candidates eligible for their first blood donation underwent a socio‐epidemiological interview, and blood samples were collected for enzyme‐linked immunosorbent assay (ELISA) analysis, Western blot and polymerase chain reaction (PCR). Patients transfused with red blood cells or random platelet concentrates collected from these donors were also studied. The results were analysed using descriptive statistics and prevalence estimates, with significance defined as p‐values <0·05. Results Of the 608 eligible donors, 37 (6·1%) were positive for visceral leishmaniasis as per ELISA. The socio‐epidemiological analysis showed a significantly higher prevalence in non‐Caucasians (p = 0·008). Among 296 patients who received blood components from these donors, the pre‐transfusion seropositivity was 7·7%, and 13 patients received blood positive for Leishmania infantum. Six patients were followed up for 90 days, of which two (33·3%) had serological conversion at 60 days. Conclusions The results confirm the high prevalence of L. infantum seropositivity among donors in the three regions; the seroconversion in a short period of time in two of six patients suggests the possibility of transmission of the infection by transfusion.pt_BR
dc.languageen_USpt_BR
dc.publisherWileypt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceTransfusion Medicinept_BR
dc.subjectBlood donorspt_BR
dc.subjectBlood transfusionpt_BR
dc.subjectLeishmania infantumpt_BR
dc.subjectVisceral leishmaniasispt_BR
dc.titleSocio‐epidemiological characterisation of blood donors with asymptomatic Leishmania infantum infection from three Brazilian endemic regions and analysis of the transfusional transmission risk of visceral leishmaniasispt_BR
dc.typeArtigopt_BR
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