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Campo DCValorIdioma
dc.creatorMoreira, Lucimara Q.-
dc.creatorVilela, Fabiana C.-
dc.creatorOrlandi, Lidiane-
dc.creatorDias, Danielle F.-
dc.creatorSantos, Ana Laura A.-
dc.creatorSilva, Marcelo A. da-
dc.creatorPaiva, Renato-
dc.creatorAlves-da-Silva, Geraldo-
dc.creatorGiusti-Paiva, Alexandre-
dc.date.accessioned2020-02-05T21:17:20Z-
dc.date.available2020-02-05T21:17:20Z-
dc.date.issued2011-11-
dc.identifier.citationMOREIRA, L. Q. et al. Anti-inflammatory effect of extract and fractions from the leaves of Byrsonima intermedia A. Juss. in rats. Journal of Ethnopharmacology, [S.l.], v. 138, n. 2, p. 610-615, Nov. 2011. DOI: 10.1016/j.jep.2011.10.006.pt_BR
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0378874111007331pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/38858-
dc.description.abstractAim of the study: Byrsonima intermedia is commonly used for its antiseptic, antimicrobial, and anti-inflammatory properties in the treatment of diarrhea and dysentery in Brazilian folk medicine. The purpose of this study was to examine the anti-inflammatory activity of the aqueous extract and fractions of Byrsonima intermedia leaves. Materials and methods: rats with carrageenan-induced paw edema and fibrovascular tissue growth, which was induced by subcutaneous implantation of a cotton pellet, were used as acute and chronic animal models of inflammation to investigate the anti-inflammatory effects of the aqueous extract and the individual ethyl acetate (EtOAc) and aqueous fractions of Byrsonima intermedia and catechin. High-performance liquid chromatography (HPLC) was used to determine the fingerprint chromatogram of the aqueous extract and fractions of Byrsonima intermedia. Results: the crude aqueous extract at test doses of 30–300 mg/kg p.o. clearly demonstrated anti-inflammatory effects by reducing carrageenan-induced paw edema, as did the ethyl acetate (100 mg/kg) and aqueous fractions (30–100 mg/kg). In the chronic inflammation rat animal model with fibrovascular tissue growth, the aqueous extract of Byrsonima intermedia (BiAE) at doses of 30–300 mg/kg and the individual EtOAc and aqueous fractions at doses of 30–100 mg/kg and catechin significantly reduced the formation of granulomatous tissue. The presence of catechin and phenolic compounds in the extract and fractions of Byrsonima intermedia was confirmed using HPLC. Conclusion: BiAE and the individual EtOAc and aqueous fractions of Byrsonima intermedia exhibited chronic and acute anti-inflammatory efficacy in rats, which supports previous claims of its use in traditional medicine.pt_BR
dc.languageen_USpt_BR
dc.publisherElsevierpt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceJournal of Ethnopharmacologypt_BR
dc.subjectAnti-inflammatory activitypt_BR
dc.subjectByrsonima intermediapt_BR
dc.subjectCatechinpt_BR
dc.subjectChromatographic fingerprintspt_BR
dc.subjectFlavonoidspt_BR
dc.subjectMalphigiaceaept_BR
dc.titleAnti-inflammatory effect of extract and fractions from the leaves of Byrsonima intermedia A. Juss. in ratspt_BR
dc.typeArtigopt_BR
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