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Campo DCValorIdioma
dc.creatorJesus, Marcelo Bispo de-
dc.creatorPinto, Luciana de Mato Alves-
dc.creatorFraceto, Leonardo Fernandes-
dc.creatorMagalhães, Luiz Augusto-
dc.creatorZanotti-Magalhães, Eliana Maria-
dc.creatorPaula, Eneida de-
dc.date.accessioned2020-02-07T12:19:35Z-
dc.date.available2020-02-07T12:19:35Z-
dc.date.issued2010-
dc.identifier.citationJESUS, M. B. de et al. Improvement of the oral praziquantel anthelmintic effect by cyclodextrin complexation. Journal of Drug Targeting, Abingdon, v. 18, n. 1, p. 21-26, 2010.pt_BR
dc.identifier.urihttps://www.tandfonline.com/doi/abs/10.3109/10611860903131677pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/38958-
dc.description.abstractSchistosomiasis is a parasitic disease which kills a half million people per year, all over the world. Praziquantel (PZQ) is the drug-of-choice for schistosomiasis because of its effectiveness, ease of administration, and low cost. However, poor solubility restricts its delivery, especially via the oral route. In this study, we describe β-cyclodextrin (β-CD) complexation as an alternative to improve the PZQ bioavailability. Physicochemical analysis were performed to characterize the inclusion complex formed between PZQ and β-CD. Differential scanning calorimetry (DSC) thermograms and morphological analysis using scanning electronic microscopy (SEM) gave evidences of the complex formation. Diffusion NMR experiments allowed determination of the fraction of PZQ bound to β-CD (37%) and the association constant (941 ± 47 M−1). The in vivo evaluation of the complexation on the effect of PZQ was performed on mice infected with Schistosoma mansoni (BH strain); after 15 days of treatment with the PZQ:β-CD complex the efficacy, evaluated by the number of remaining alive worms, was 99%, against 59% elicited by plain PZQ.pt_BR
dc.languageenpt_BR
dc.publisherTaylor & Francis Ltd.pt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceJournal of Drug Targetingpt_BR
dc.subjectPraziquantelpt_BR
dc.subjectCyclodextrinpt_BR
dc.subjectInclusion complexpt_BR
dc.subjectSchistosomiasispt_BR
dc.titleImprovement of the oral praziquantel anthelmintic effect by cyclodextrin complexationpt_BR
dc.typeArtigopt_BR
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