1. RI UFLA
  2. Faculdade de Ciências da Saúde - FCS
  3. FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)
Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/40754
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dc.creatorPerrotta, Fábio-
dc.creatorMatera, Maria Gabriella-
dc.creatorCazzola, Mario-
dc.creatorBianco, Andrea-
dc.date.accessioned2020-05-09T01:07:59Z-
dc.date.available2020-05-09T01:07:59Z-
dc.date.issued2020-07-
dc.identifier.citationPERROTTA, F. et al. Severe respiratory SARS-CoV2 infection: does ACE2 receptor matter? Respiratory Medicine, [S.l.], v. 168, July 2020.pt_BR
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0954611120301360pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/40754-
dc.description.abstractSARS-CoV-2 is a novel virus of the Coronaviridiae family that represents a major global health issue. Mechanisms implicated in virus/host cells interaction are central for cell infection and replication that in turn lead to disease onset and local damage. To enter airway and lung epithelia, SARS-CoV-2 attaches to ACE2 receptors by spike (S) glycoproteins. Molecular mechanisms that promote interaction between SARS-CoV-2 virus and host with particular focus on virus cell entry receptor ACE2 are described. We further explore the impact of underlying medical conditions and therapies including renin-angiotensin inhibitors on modulating ACE 2, which is the major SARS-CoV-2 cell entry receptor.pt_BR
dc.languageen_USpt_BR
dc.publisherElsevierpt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceRespiratory Medicinept_BR
dc.subjectSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)pt_BR
dc.subjectACE-2 receptorpt_BR
dc.subjectACE inhibitorspt_BR
dc.subjectRenin-angiotensin inhibitorspt_BR
dc.titleSevere respiratory SARS-CoV2 infection: does ACE2 receptor matter?pt_BR
dc.typeArtigopt_BR
Appears in Collections:FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)

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