Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/41256
Título : The CoV-2 outbreak: how hematologists could help to fight Covid-19
Autor: Galimberti, Sara
Baldini, Chiara
Baratè, Claudia
Ricci, Federica
Balducci, Serena
Grassi, Susanna
Ferro, Francesco
Buda, Gabriele
Benedetti, Edoardo
Fazzi, Rita
Baglietto, Laura
Lucenteforte, Ersilia
Di Paolo, Antonello
Petrini, Mario
Palavras-chave: COVID-19
Ruxolitinib
Tyrosine kinase inhibitors (TKIs)
Begelomab
Baricitinib
Tocilizumab
Acute graft-versus-host disease (aGVHD)
Macrophage activation syndrome (MAS)
Publicador: Elsevier
Data da publicação: Jul-2020
Referência: GALIMBERTI, S. et al. The CoV-2 outbreak: how hematologists could help to fight Covid-19. Pharmacological Research, [S.l.], v. 157, July 2020.
Abstract: COVID-19 is a medical emergency, with 20 % of patients presenting with severe clinical manifestations. From the pathogenetic point of view, COVID-19 mimics two other well-known diseases characterized by cytokine storm and hyper-activation of the immune response, with consequent organ damage: acute graft-versus-host disease (aGVHD) and macrophage activation syndrome (MAS). Hematologists are confident with these situations requiring a prompt therapeutic approach for switching off the uncontrolled cytokine release; here, we discuss pros and cons of drugs that are already employed in hematology in the light of their possible application in COVID-19. The most promising drugs might be: Ruxolitinib, a JAK1/2 inhibitor, with a rapid and powerful anti-cytokine effect, tyrosine kinase inhibitors (TKIs), with their good anti-inflammatory properties, and perhaps the anti-Cd26 antibody Begelomab. We also present immunological data from gene expression experiments where TKIs resulted effective anti-inflammatory and pro-immune drugs. A possible combined treatment algorithm for COVID-19 is here proposed.
URI: http://www.sciencedirect.com/science/article/pii/S1043661820311749
http://repositorio.ufla.br/jspui/handle/1/41256
Idioma: en_US
Aparece nas coleções:FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)

Arquivos associados a este item:
Não existem arquivos associados a este item.


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.