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dc.creatorBressani, F.A.-
dc.creatorTizioto, P.C.-
dc.creatorGiglioti, R.-
dc.creatorMeirelles, S. L. C.-
dc.creatorCoutinho, R.-
dc.creatorBenvenuti, C. L.-
dc.creatorMalagó-Jr., W.-
dc.creatorMudadu, M. A.-
dc.creatorVieira, L. S.-
dc.creatorZaros, L. G.-
dc.creatorCarrilho, E.-
dc.creatorRegitano, L. C. A.-
dc.date.accessioned2020-07-13T13:22:21Z-
dc.date.available2020-07-13T13:22:21Z-
dc.date.issued2014-10-20-
dc.identifier.citationBRESSANI, F. A. et al. Single nucleotide polymorphisms in candidate genes associated with gastrointestinal nematode infection in goats. Genetics and Molecular Research, Ribeirão Preto, v. 13, n. 4, p. 8530-8536, Oct. 2014. DOI: 10.4238/2014.October.20.29.pt_BR
dc.identifier.urihttps://www.geneticsmr.com/articles/3631pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/41909-
dc.description.abstractCytokines are small cell-signaling proteins that play an important role in the immune system, participating in intracellular communication. Four candidate genes of the cytokine family (IL2, IL4, IL13, and IFNG) were selected to identify Single Nucleotide Polymorphisms (SNPs) that might be associated with resistance to gastrointestinal endoparasites in goats. A population of 229 goats, F2 offspring from an F1 intercross was produced by crossing pure Saanen goats, considered as susceptible to gastrointestinal endoparasites, with pure Anglo-Nubian goats, considered resistant. Blood was collected for DNA extraction and fecal samples were also collected for parasite egg count. Polymorphisms were prospected by sequencing animals with extreme phenotype for fecal egg count (FEC) distribution. The association between SNPs and phenotype was determined by using the Fisher exact test with correction for multiple tests. Three of the 10 SNPs were identified as significant (P ≤ 0.03). They were found in intron 1 of IL2 (ENSBTA00000020883), intron 3 of IL13 (ENSBTA00000015953) and exon 3 of IFNG (ENSBTA00000012529), suggesting an association between them and gastrointestinal endoparasite resistance. Further studies will help describe the effects of these markers accurately before implementing them in marker assisted selection. This study is the pioneer in describing such associations in goats. Cytokines are small cell-signaling proteins that play an important role in the immune system, participating in intracellular communication. Four candidate genes of the cytokine family (IL2, IL4, IL13, and IFNG) were selected to identify Single Nucleotide Polymorphisms (SNPs) that might be associated with resistance to gastrointestinal endoparasites in goats. A population of 229 goats, F2 offspring from an F1 intercross was produced by crossing pure Saanen goats, considered as susceptible to gastrointestinal endoparasites, with pure Anglo-Nubian goats, considered resistant. Blood was collected for DNA extraction and fecal samples were also collected for parasite egg count. Polymorphisms were prospected by sequencing animals with extreme phenotype for fecal egg count (FEC) distribution. The association between SNPs and phenotype was determined by using the Fisher exact test with correction for multiple tests. Three of the 10 SNPs were identified as significant (P ≤ 0.03). They were found in intron 1 of IL2 (ENSBTA00000020883), intron 3 of IL13 (ENSBTA00000015953) and exon 3 of IFNG (ENSBTA00000012529), suggesting an association between them and gastrointestinal endoparasite resistance. Further studies will help describe the effects of these markers accurately before implementing them in marker assisted selection. This study is the pioneer in describing such associations in goats.pt_BR
dc.languageen_USpt_BR
dc.publisherFundação de Pesquisas Científicas de Ribeirão Preto (FUNPEC-RP)pt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceGenetics and Molecular Research (GMR)pt_BR
dc.subjectSingle nucleotide polymorphismpt_BR
dc.subjectCapra hircuspt_BR
dc.subjectCytokinept_BR
dc.subjectGastrointestinal infectionpt_BR
dc.titleSingle nucleotide polymorphisms in candidate genes associated with gastrointestinal nematode infection in goatspt_BR
dc.typeArtigopt_BR
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