Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/42110
Registro completo de metadados
Campo DCValorIdioma
dc.creatorTiburcio, Monique Gomes Salles-
dc.creatorAnversa, Laís-
dc.creatorKanunfre, Kelly Aparecida-
dc.creatorFerreira, Antonio Walter-
dc.creatorRodrigues Júnior, Virmondes-
dc.creatorSilva, Luciana de Almeida-
dc.date.accessioned2020-07-24T18:11:07Z-
dc.date.available2020-07-24T18:11:07Z-
dc.date.issued2013-11-
dc.identifier.citationTIBURCIO, M. G. S. et al. Anti-leishmania infantum IgG antibody avidity in visceral leishmaniasis. Clinical and Vaccine Immunology, Washington, v. 20, n. 11, p. 1679-1702, Nov. 2013.pt_BR
dc.identifier.urihttps://cvi.asm.org/content/20/11/1697pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/42110-
dc.description.abstractIgG avidity tests are used to discriminate acute from chronic infections. There are few reports on the IgG avidity profile of patients with visceral leishmaniasis (VL). This study investigated the anti-Leishmania IgG avidity in patients with classic VL (n = 10), patients showing clinical cure after treatment (n = 18), and asymptomatic subjects with at least one positive Leishmania test (n = 20). All subjects were from areas in Brazil where VL is endemic. Serum samples were collected from each subject on two different occasions. IgG avidity was evaluated by Western blotting. The proportion of high-avidity antibodies was higher in all samples from patients with classic VL. In contrast, low-avidity antibodies predominated in subjects with a history of VL, including 13 cases (72.2%) in the first assessment and 14 (77.8%) in the second. Fifteen (75%) of the asymptomatic subjects presented a predominance of low-avidity antibodies in the first assessment, and the frequency of high-avidity antibodies increased over time in seven subjects (35%) of this group. Antibodies against the 14- and/or 16-kDa antigen fraction were detected in the first assessment in all patients with classic VL, in 10 (55.5%) treated patients, and in 10 (50%) asymptomatic subjects. These were high-avidity antibodies in most cases. In the asymptomatic group, an increase in IgG avidity against the 14- and/or 16-kDa antigen fraction was observed in three cases (15%). The results indicate distinct responses in infected and asymptomatic subjects, probably associated with the length of time after infection. In this respect, IgG avidity tests represent a new approach to better characterize asymptomatic VL.pt_BR
dc.languageen_USpt_BR
dc.publisherAmerican Society for Microbiologypt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceClinical and Vaccine Immunologypt_BR
dc.subjectVisceral leishmaniasispt_BR
dc.subjectLeishmaniose visceralpt_BR
dc.titleAnti-leishmania infantum IgG antibody avidity in visceral leishmaniasispt_BR
dc.typeArtigopt_BR
Aparece nas coleções:DME - Artigos publicados em periódicos

Arquivos associados a este item:
Não existem arquivos associados a este item.


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.