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http://repositorio.ufla.br/jspui/handle/1/42182
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DC Field | Value | Language |
---|---|---|
dc.creator | Sternberg, Ariane | - |
dc.creator | Naujokat, Cord | - |
dc.date.accessioned | 2020-08-03T16:09:46Z | - |
dc.date.available | 2020-08-03T16:09:46Z | - |
dc.date.issued | 2020-09 | - |
dc.identifier.citation | STERNBERG, A.; NAUJOKAT, C. Structural features of coronavirus SARS-CoV-2 spike protein: targets for vaccination. Life Sciences, [S.l.], v. 257, Sept. 2020. | pt_BR |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0024320520308079 | pt_BR |
dc.identifier.uri | http://repositorio.ufla.br/jspui/handle/1/42182 | - |
dc.description.abstract | Various human pathogenic viruses employ envelope glycoproteins for host cell receptor recognition and binding, membrane fusion and viral entry. The spike (S) glycoprotein of betacoronavirus SARS-CoV-2 is a homotrimeric class I fusion protein that exists in a metastable conformation for cleavage by host cell proteases furin and TMPRSS2, thereby undergoing substantial structural rearrangement for ACE2 host cell receptor binding and subsequent viral entry by membrane fusion. The S protein is densely decorated with N-linked glycans protruding from the trimer surface that affect S protein folding, processing by host cell proteases and the elicitation of humoral immune response. Deep insight into the sophisticated structure of SARS-CoV-2 S protein may provide a blueprint for vaccination strategies, as reviewed herein. | pt_BR |
dc.language | en_US | pt_BR |
dc.publisher | Elsevier | pt_BR |
dc.rights | restrictAccess | pt_BR |
dc.source | Life Sciences | pt_BR |
dc.subject | Coronavirus | pt_BR |
dc.subject | Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) | pt_BR |
dc.subject | Spike protein | pt_BR |
dc.subject | Protein structure | pt_BR |
dc.subject | Receptor binding domain | pt_BR |
dc.subject | Viral fusion protein | pt_BR |
dc.subject | Angiotensin-converting enzyme 2 (ACE2) | pt_BR |
dc.subject | Vaccination | pt_BR |
dc.subject | Immune response | pt_BR |
dc.title | Structural features of coronavirus SARS-CoV-2 spike protein: targets for vaccination | pt_BR |
dc.type | Artigo | pt_BR |
Appears in Collections: | FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19) |
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