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dc.creatorGupta, Pramod Kumar-
dc.date.accessioned2020-08-04T16:14:01Z-
dc.date.available2020-08-04T16:14:01Z-
dc.date.issued2020-10-
dc.identifier.citationGUPTA, P. K. New disease old vaccine: is recombinant BCG vaccine an answer for COVID-19? Cellular Immunology, [S.l.], v. 356, Oct. 2020.pt_BR
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0008874920303476pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/42194-
dc.description.abstractMycobacterium bovis BCG, a live attenuated tuberculosis vaccine offers protection against disseminated TB in children. BCG exhibits heterologous protective effects against unrelated infections and reduces infant mortality due to non-mycobacterial infections. Recent reports have suggested that BCG vaccination might have protective effects against COVID-19, however it is highly unlikely that BCG vaccine in its current form can offer complete protection against SARS-CoV-2 infection due to the lack of specific immunity. Nonetheless, recombinant BCG strains expressing antigens of SARS-CoV-2 may offer protection against COVID-19 due to the activation of innate as well as specific adaptive immune response. Further proven safety records of BCG in humans, its adjuvant activity and low cost manufacturing makes it a frontrunner in the vaccine development to stop this pandemic. In this review we discuss about the heterologous effects of BCG, induction of trained immunity and its implication in development of a potential vaccine against COVID-19 pandemic.pt_BR
dc.languageen_USpt_BR
dc.publisherElsevierpt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceCellular Immunologypt_BR
dc.subjectSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)pt_BR
dc.subjectCOVID-19pt_BR
dc.subjectBCG vaccinept_BR
dc.subjectTrained immunitypt_BR
dc.titleNew disease old vaccine: is recombinant BCG vaccine an answer for COVID-19?pt_BR
dc.typeArtigopt_BR
Aparece nas coleções:FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)

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