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dc.creatorSilva, Karla Christina Sousa-
dc.creatorSilva, Lana O’Hara Souza-
dc.creatorSilva, Guilherme Algusto Alves-
dc.creatorBorges, Clayton Luiz-
dc.creatorNovaes, Evandro-
dc.creatorPaccez, Juliano Domiraci-
dc.creatorFontes, Wagner-
dc.creatorMarval, Marcia Giambiagi-de-
dc.creatorSoares, Célia Maria de Almeida-
dc.creatorParente-Rocha, Juliana Alves-
dc.date.accessioned2020-09-01T19:56:23Z-
dc.date.available2020-09-01T19:56:23Z-
dc.date.issued2020-
dc.identifier.citationSILVA, K. C. S. et al. Staphylococcus saprophyticus proteomic analyses elucidate differences in the protein repertories among clinical strains related to virulence and persistence. Pathogens, [S.l.], v. 91, n. 1, 2020.pt_BR
dc.identifier.urihttps://www.mdpi.com/2076-0817/9/1/69pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/42800-
dc.description.abstractStaphylococcus saprophyticus is a Gram-positive and coagulase negative cocci that composes the skin microbiota and can act as an opportunistic agent causing urinary tract infections, being more frequent in sexually active young women. The ability of a pathogen to cause infection in the host is associated to its ability to adhere to host cells and to survive host immune defenses. In this work, we presented the comparative proteomic profile of three S. saprophyticus strains. It was possible to characterize differences in the proteome content, specially related to expression of virulence factors. We compiled this data and previous data and we detected one strain (9325) possessing higher production and secretion of proteins related to virulence. Our results show that phenotypic, genotypic, and proteomic differences reflect in the ability to survive during interaction with host cells, since the 9325 strain presented a higher survival rate after macrophage interaction. In counterpart, the 7108 strain that possesses lower content of proteins related to virulence presented higher ability to form biofilm suggesting that this strain can be better adapted to persist in the host and in the environment. Our work describes, for the first time, proteomic flexibility among S. saprophyticus strains, reflecting in virulence and persistence.pt_BR
dc.languageen_USpt_BR
dc.publisherMultidisciplinary Digital Publishing Institutept_BR
dc.rightsrestrictAccesspt_BR
dc.sourcePathogenspt_BR
dc.subjectProteomept_BR
dc.subjectProteomic flexibilitypt_BR
dc.subjectVirulencept_BR
dc.subjectUreasept_BR
dc.subjectThioredoxinpt_BR
dc.subjectBiofilmpt_BR
dc.titleStaphylococcus saprophyticus proteomic analyses elucidate differences in the protein repertories among clinical strains related to virulence and persistencept_BR
dc.typeArtigopt_BR
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