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dc.creatorUddin Bhuiyan, Mejbah-
dc.creatorStiboy, Eunice-
dc.creatorHassan, Zakiul-
dc.creatorChan, Mei-
dc.creatorIslam, Saiful-
dc.creatorHaider, Najmul-
dc.creatorJaffe, Adam-
dc.creatorHomaira, Nusrat-
dc.date.accessioned2020-12-11T17:18:36Z-
dc.date.available2020-12-11T17:18:36Z-
dc.date.issued2020-
dc.identifier.citationUDDIN BHUIYAN, M. et al. Epidemiology of COVID-19 infection in young children under five years: a systematic review and meta-analysis. Vaccine, [S.l.], 2020. No prelo.pt_BR
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0264410X2031570X#!pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/45853-
dc.description.abstractIntroduction Emerging evidence suggests young children are at greater risk of COVID-19 infection than initially predicted. However, a comprehensive understanding of epidemiology of COVID-19 infection in young children under five years, the most at-risk age-group for respiratory infection, remain unclear. We conducted a systematic review and meta-analysis of epidemiological and clinical characteristics of COVID-19 infection in children under five years. Method Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, we searched several electronic databases (Pubmed, EMBASE, Web of Science, and Scopus) with no language restriction for published epidemiological studies and case-reports reporting laboratory-confirmed COVID-19 infection in children under five years until June 4, 2020. We assessed pooled prevalence for key demographics and clinical characteristics using Freeman-Tukey double arcsine random-effects model for studies except case-reports. We evaluated risk of bias separately for case-reports and other studies. Results We identified 1,964 articles, of which, 65 articles were eligible for systematic review that represented 1,214 children younger than five years with laboratory-confirmed COVID-19 infection. The pooled estimates showed that 50% young COVID-19 cases were infants (95% CI: 36% - 63%, 27 studies); 53% were male (95% CI: 41% - 65%, 24 studies); 43% were asymptomatic (95% CI: 15% - 73%, 9 studies) and 7% (95% CI: 0% - 30%, 5 studies) had severe disease that required intensive-care-unit admission. Of 139 newborns from COVID-19 infected mothers, five (3.6%) were COVID-19 positive. There was only one death recorded. Discussion This systematic review reports the largest number of children younger than five years with COVID-19 infection till date. Our meta-analysis shows nearly half of young COVID-19 cases were asymptomatic and half were infants, highlighting the need for ongoing surveillance to better understand the epidemiology, clinical pattern, and transmission of COVID-19 to develop effective preventive strategies against COVID-19 disease in young paediatric populationpt_BR
dc.languageen_USpt_BR
dc.publisherElsevierpt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceVaccinept_BR
dc.subjectCOVID-19pt_BR
dc.subjectCOVID-19 newbornspt_BR
dc.titleEpidemiology of COVID-19 infection in young children under five years: a systematic review and meta-analysispt_BR
dc.typeArtigopt_BR
Aparece nas coleções:FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)

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