Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/48806
Registro completo de metadados
Campo DCValorIdioma
dc.creatorEsposito, Mariana Araújo-
dc.creatorCesar, Pedro Henrique Souza-
dc.creatorBrandão, Rafaela Magalhães-
dc.creatorAbreu, Tatiane Silva de-
dc.creatorMarcussi, Silvana-
dc.date.accessioned2022-01-07T15:32:34Z-
dc.date.available2022-01-07T15:32:34Z-
dc.date.issued2021-
dc.identifier.citationESPOSITO, M. A. et al. Eucalyptus grandis and Eucalyptus microcorys essential oils: in vitro modulation of hemostasis and genotoxic activity. Brazilian Archives of Biology and Technology, [S.l.], v. 64, p. 1-10, 2021. DOI: 10.1590/1678-4324-2021210109.pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/48806-
dc.description.abstractThe genus Eucalyptus present high content of essential oil (EO). This study evaluated the pharmacological properties of Eucalyptus grandis (EG) and Eucalyptus microcorys (EM) EOs. The major component in both EOs was 1,8-Cineole. Both essential oils prevented thrombus dissolution and reduced clotting, hemolysis, and genotoxicity induced by snake venoms. 50% (EM) and 73% (EG) were the greatest inhibitions obtained in the thrombolytic assay - thrombolysis induced by B. moojeni venom. Increases in clotting time were also observed, with values considered significant between 10-27 seconds. Lysis values 50% lower than the negative control were observed in both EOs. The EOs also protected fibrinogenolysis induced by snake venom. EM EO was more effective in reducing venom-induced DNA fragmentation in the comet assay, with arbitrary unit values 66.15% lower than the positive control. These oils present wide application potential considering the pharmacological properties observed in this study.pt_BR
dc.languageen_USpt_BR
dc.publisherWileypt_BR
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rightsacesso abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.sourceBrazilian Archives of Biology and Technologypt_BR
dc.subject1,8-cineolept_BR
dc.subjectSnake venom proteasespt_BR
dc.subjectComet assaypt_BR
dc.subjectChemical characterizationpt_BR
dc.subjectEnzyme inhibitorspt_BR
dc.subjectHemostasispt_BR
dc.titleEucalyptus grandis and Eucalyptus microcorys essential oils: in vitro modulation of hemostasis and genotoxic activitypt_BR
dc.typeArtigopt_BR
Aparece nas coleções:DQI - Artigos publicados em periódicos



Este item está licenciada sob uma Licença Creative Commons Creative Commons