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dc.creatorNogueira, Jéssica Oliveira e-
dc.creatorCampolina, Gabriela Aguiar-
dc.creatorBatista, Luís Roberto-
dc.creatorAlves, Eduardo-
dc.creatorCaetano, Alex Rodrigues Silva-
dc.creatorBrandão, Rafaela Magalhães-
dc.creatorNelson, David Lee-
dc.creatorCardoso, Maria das Graças-
dc.date.accessioned2022-07-13T22:36:38Z-
dc.date.available2022-07-13T22:36:38Z-
dc.date.issued2021-05-
dc.identifier.citationNOGUEIRA, J. O. e et al. Mechanism of action of various terpenes and phenylpropanoids against Escherichia coli and Staphylococcus aureus. FEMS Microbiology Letters, Amsterdam, v. 368, n. 9, 2021. DOI: 10.1093/femsle/fnab052.pt_BR
dc.identifier.urihttps://doi.org/10.1093/femsle/fnab052pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/50591-
dc.description.abstractFoodborne, disease-causing microorganisms are increasingly resistant to commercial antibiotics. Thus, there is a need for the development of new agents capable of acting efficiently in the control of these pathogens. Terpenoids and phenylpropanoids stand out for having high biological activity and a broad spectrum of action. The objectives of this study were to evaluate the antibacterial potential of limonene, β-citronellol, carvone, carvacrol, eugenol and trans-cinnamaldehyde and to investigate the mechanism of activity of these compounds against the bacteria Escherichia coli and Staphylococcus aureus. The terpene and phenylpropanoid compoundswere purchased and their antibacterial potential was assessed by macrodilution. The mechanism of action was verified by tests of potassium ion efflux, salt tolerance, extravasation of cellular contents, absorption of crystal violet and morphological changes analyzed by electron microscopy. Bacteriostatic and bactericidal effects caused by the compounds carvone, carvacrol, eugenol and transcinemaldehyde were observed in both species; antibacterial activity against only S. aureus was observed for β-citronelol and limonene. Reduced salt tolerance was found for strains of E. coli treated with carvacrol and S. aureus treated with β-citronelol. There was extravasation of cellular materials induced by treatments with carvone, carvacrol, eugenol and trans-cinnamaldehyde in both microorganisms. The absorption of crystal violet increased for E. coli after incubation with each treatment. Deleterious effects and morphological changes were observed. Therefore, the monoterpenes and phenylpropanoids under study are potentially applicable for antimicrobial use against E. coli and S. aureus, and the mechanism of action involves changes in membrane permeability without cell lysis.pt_BR
dc.languageen_USpt_BR
dc.publisherOxford Academicpt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceFEMS Microbiology Letterspt_BR
dc.subjectMonoterpenespt_BR
dc.subjectPhenylpropanoidspt_BR
dc.subjectMechanism of activitypt_BR
dc.subjectMonoterpenospt_BR
dc.subjectFenilpropanóidespt_BR
dc.subjectMecanismo de atividadept_BR
dc.titleMechanism of action of various terpenes and phenylpropanoids against Escherichia coli and Staphylococcus aureuspt_BR
dc.typeArtigopt_BR
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