Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/54400
Registro completo de metadados
Campo DCValorIdioma
dc.creatorSouza, Rafaela Vieira-
dc.creatorIonta, Marisa-
dc.creatorBorges, Cleber-
dc.creatorFerreira, Vanuzia Rodrigues Fernandes-
dc.creatorCaetano, Alex Rodrigues Silva-
dc.creatorCampolina, Gabriela Aguiar-
dc.creatorHorvath, Renato de Oliveira-
dc.creatorNelson, David Lee-
dc.creatorCardoso, Maria das Graças-
dc.date.accessioned2022-08-31T16:40:41Z-
dc.date.available2022-08-31T16:40:41Z-
dc.date.issued2022-03-
dc.identifier.citationSOUZA, R. V. et al. Antioxidant and antitumoral potential of terpenes and phenylpropanoids against MCF7, A549 and HT144 cancer cell lines. Australian Journal of Crop Science, [S.l.], v. 16, p. 372-380, 2022. DOI: 10.21475/ajcs.22.16.03.p3395.pt_BR
dc.identifier.urihttps://www.cropj.com/march2022.htmlpt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/54400-
dc.description.abstractEssential oils are a complex mixture of terpenes and phenylpropanoids that have several biological activities, including antioxidant and antitumoral activities. The present study sought to evaluate the antioxidant potential of monoterpenes and phenylpropanoids by different methods (stabilization of free radicals, inhibition of lipid peroxidation, and complexation of metals). In addition, the antitumor potentials of these compounds were evaluated on human estrogen-positive breast cancer (MCF-7), non-small cell lung cancer (A-549), and melanoma cancer (HT-144) cell lines. Cisplatin (6 µg mL-1) was used as a positive control. The cell viability was studied and the quantification of DNA was performed. The antioxidant activity results were analyzed by linear regression and antitumor activity were analyzed via analysis of variance and the Dunnett test. A greater antioxidant activity was observed for the phenolic compounds carvacrol, thymol and eugenol than for the standards (BHT, mannitol and ascorbic acid) by the methods tested. A dose-response effect was observed for the less active compounds, revealing the influence of the concentration of the constituents. Carvacrol displayed an important cytotoxic activity against the estrogen-positive MCF-7 cell line, and citral was more active against A549 cells and HT144 melanoma cells. The positive control Cisplatin showed low cell viability over the A549 and HT44 cells, and showed high cell viability over the MCF-7 cell. The antitumor activity of citral observed against HT144 cells is associated with its ability to promote the cell cycle at the G1/S transition, at least in part.pt_BR
dc.languageen_USpt_BR
dc.publisherSouthern Cross Publishingpt_BR
dc.rightsrestrictAccesspt_BR
dc.sourceAustralian Journal of Crop Science (AJCS)pt_BR
dc.subjectEssential oilspt_BR
dc.subjectMonoterpenespt_BR
dc.subjectPhenylpropanoidpt_BR
dc.subjectFree radicalspt_BR
dc.subjectLipid peroxidationpt_BR
dc.subjectMetalspt_BR
dc.titleAntioxidant and antitumoral potential of terpenes and phenylpropanoids against MCF7, A549 and HT144 cancer cell linespt_BR
dc.typeArtigopt_BR
Aparece nas coleções:DQI - Artigos publicados em periódicos

Arquivos associados a este item:
Não existem arquivos associados a este item.


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.