Navegando por Assunto Acetylcholinesterase

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Data do documentoTítuloAutor(es)
2023Assessing the therapeutic and toxicological profile of novel acetylcholinesterase reactivators: value of in silico and in vitro dataRamalho, Teodorico de C.; Castro, Alexandre A. de; Leal, Daniel H.S.; Teixeira, Jessika P.; Cunha, Elaine F.F. da; Kuca, Kamil
Jun-2017Biochemical response of the Africanized honeybee exposed to fipronilRoat, Thaisa C.; Carvalho, Stephan M.; Palma, Mário S.; Malaspina, Osmar
2014Computational evidence for the reactivation process of human acetylcholinesterase inhibited by carbamatesMatos, Karina Silva; Cunha, Elaine F. F. da; Abagyan, Ruben; Ramalho, Teodorico C.
15-Abr-2010Development of new acetylcholinesterase reactivators: molecular modeling versus in vitro dataRamalho, Teodorico C.; França, Tanos C.C.; Rennó, Magdalena N.; Guimarães, Ana P.; Cunha, Elaine F. F. da; Kuča, Kamil
2016Docking and molecular dynamics studies of peripheral site ligand–oximes as reactivators of sarin-inhibited human acetylcholinesteraseAlmeida, Joyce S. F. D. de; Guizado, Teobaldo R. Cuya; Guimarães, Ana P.; Ramalho, Teodorico C.; Gonçalves, Arlan S.; Koning, Martijn C. de; França, Tanos C. C.
2011Docking studies and effects of syn-anti isomery of oximes derived from pyridine imidazol bicycled systems as potential human acetylcholinesterase reactivatorsGuimarães, Ana Paula; França, Tanos Celmar Costa; Ramalho, Teodorico Castro; Rennó, Magdalena Nascimento; Matos, Karina Silvia; Mancini, Daiana Teixeira; Kuča, Kamil
2013Estudos in silico de potenciais inibidores da enzima di-hidrifolato redutase de Bacillus anthracis e de uma oxima reativadora da acetilcolinesteraseSilva, Juliana de Oliveira
18-Jan-2022Eugenia uniflora, Melaleuca armillaris, and Schinus molle essential oils to manage larvae of the filarial vector Culex quinquefasciatus (Diptera: Culicidae)Oliveira, Júlia Assunção de Castro; Ferreira, Lorena Sales; Garcia, Israel Pereira; Santos, Hérica de Lima; Ferreira, Gustavo Sales; Rocha, João Pedro Miranda; Nunes, Stênio Alves; Carvalho, Alexandre Alves de; Pinto, José Eduardo Brasil Pereira; Bertolucci, Suzan Kelly Vilela
2012First principles calculations of thermodynamics and kinetic parameters and molecular dynamics simulations of acetylcholinesterase reactivators: can mouse data provide new insights into humans?Matos, Karina S.; Cunha, Elaine F. F. da; Gonçalves, Arlan da Silva; Wilter, Alan; Kuča, Kamil; França, Tanos C. C.; Ramalho, Teodorico C.
2016Flexibility in the molecular design of acetylcholinesterase reactivators: probing representative conformations by chemometric techniques and docking/QM calculationsLima, Willian E. A. de; Pereira, Ander F.; Castro, Alexandre A. de; Cunha, Elaine F. F. da; Ramalho, Teodorico C.
26-Abr-2017Modelagem de tetraidroquinolinas: efeito larvicida e adulticida em Aedes aegyptiGiacoppo, Juliana de Oliveira Silva
Out-2011Molecular aspects of the reactivation process of acetylcholinesterase inhibited by cyclosarinMatos, Karina S.; Mancini, Daiana T.; Cunha, Elaine F. F. da; Kuča, Kamil; França, Tanos C. C.; Ramalho, Teodorico C.
2015Molecular modeling and in vitro reactivation study between the oxime BI-6 and acetylcholinesterase inhibited by different nerve agentsGiacoppo, Juliana O. S.; França, Tanos C. C.; Kuča, Kamil; Cunha, Elaine F. F. da; Abagyan, Ruben; Mancini, Daiana Teixeira; Ramalho, Teodorico C.
2019Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approachSilva, Jorge Alberto Valle da; Nepovimova, Eugenie; Ramalho, Teodorico Castro; Kuca, Kamil; França, Tanos Celmar Costa
2019Molecular modelling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime with VX-inhibited human acetylcholinesterase: a near attack approach to assess different spacer-lengthsSilva, Jorge Alberto Valle da; Nepovimova, Eugenie; Ramalho, Teodorico Castro; Kuca, Kamil; França, Tanos Celmar Costa
2019Non-conventional compounds with potential therapeutic effects against Alzheimer’s diseaseCastro, Alexandre A. de; Soares, Flávia V.; Pereira, Ander F.; Polisel, Daniel A.; Caetano, Melissa S.; Leal, Daniel H. S.; Cunha, Elaine F. F. da; Nepovimova, Eugenie; Kuca, Kamil; Ramalho, Teodorico C.
2020Reactivation of VX-inhibited human acetylcholinesterase by deprotonated pralidoxime. a complementary quantum mechanical studySilva, Jorge Alberto Valle da; Pereira, Ander Francisco; LaPlante, Steven R.; Kuca, Kamil; Ramalho, Teodorico Castro; França, Tanos Celmar Costa
2014Reactivation steps by 2-PAM of tabun-inhibited human acetylcholinesterase: reducing the computational cost in hybrid QM/MM methodsGonçalves, Arlan da Silva; França, Tanos Celmar Costa; Caetano, Melissa Soares Melissa Soares; Ramalho, Teodorico Castro
7-Mai-2018Synthesis, biological evaluation and docking studies of novel bisquaternary aldoxime reactivators on acetylcholinesterase and butyrylcholinesterase inhibited by paraoxonKuca, Kamil; Jun, Daniel; Junova, Lucie; Musilek, Kamil; Hrabinova, Martina; Silva, Jorge Alberto Valle da; Ramalho, Teodorico Castro; Valko, Marian; Wu, Qinghua; Nepovimova, Eugenie; França, Tanos Celmar Costa
6-Jun-2012The MIA-QSAR method for the prediction of bioactivities of possible acetylcholinesterase inhibitorsBitencourt, Michelle; Freitas, Matheus P.; Rittner, Roberto