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metadata.artigo.dc.title: In silico study of leishmania donovani α-β tubulin and inhibitors
metadata.artigo.dc.creator: Assis, Tamiris M.
Mancini, Daiana T.
Ramalho, Teodorico C.
Cunha, Elaine F. F. da
metadata.artigo.dc.subject: Visceral leishmaniasis
Leishmaniose visceral
metadata.artigo.dc.publisher: Hindawi Publishing Corporation 2014
metadata.artigo.dc.identifier.citation: ASSIS, T. M. et al. In silico study of leishmania donovani α-β tubulin and inhibitors. Journal of Chemistry, [S. l.], v. 2014, p. 1-8, 2014. doi:
metadata.artigo.dc.description.abstract: Leishmania donovani is a parasite that causes visceral leishmaniasis, a severe form of leishmaniasis that affects vital organs. An important target for the treatment of this disease is the protein α-β tubulin, which was modeled in this paper and proposed as a target for the treatment of visceral leishmaniasis. Two classes of compounds were studied, dinitroanilines and oxadiazoles. According to the docking results, dinitroanilines interact better with the L loop domain and oxadiazoles interact better with the colchicine domain.
metadata.artigo.dc.language: en_US
Appears in Collections:DQI - Artigos publicados em periódicos

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