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http://repositorio.ufla.br/jspui/handle/1/28496
Título: | In silico study of leishmania donovani α-β tubulin and inhibitors |
Palavras-chave: | Visceral leishmaniasis Dinitroanilines Oxadiazoles Leishmaniose visceral Dinitroanilinas |
Data do documento: | 2014 |
Editor: | Hindawi Publishing Corporation |
Citação: | ASSIS, T. M. et al. In silico study of leishmania donovani α-β tubulin and inhibitors. Journal of Chemistry, [S. l.], v. 2014, p. 1-8, 2014. doi: http://dx.doi.org/10.1155/2014/492579. |
Resumo: | Leishmania donovani is a parasite that causes visceral leishmaniasis, a severe form of leishmaniasis that affects vital organs. An important target for the treatment of this disease is the protein α-β tubulin, which was modeled in this paper and proposed as a target for the treatment of visceral leishmaniasis. Two classes of compounds were studied, dinitroanilines and oxadiazoles. According to the docking results, dinitroanilines interact better with the L loop domain and oxadiazoles interact better with the colchicine domain. |
URI: | http://repositorio.ufla.br/jspui/handle/1/28496 |
Aparece nas coleções: | DQI - Artigos publicados em periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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ARTIGO_In silico study of leishmania donovani α-β tubulin and inhibitors.pdf | 2,41 MB | Adobe PDF | Visualizar/Abrir |
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