Use este identificador para citar ou linkar para este item: http://repositorio.ufla.br/jspui/handle/1/28496
Título: In silico study of leishmania donovani α-β tubulin and inhibitors
Palavras-chave: Visceral leishmaniasis
Dinitroanilines
Oxadiazoles
Leishmaniose visceral
Dinitroanilinas
Data do documento: 2014
Editor: Hindawi Publishing Corporation
Citação: ASSIS, T. M. et al. In silico study of leishmania donovani α-β tubulin and inhibitors. Journal of Chemistry, [S. l.], v. 2014, p. 1-8, 2014. doi: http://dx.doi.org/10.1155/2014/492579.
Resumo: Leishmania donovani is a parasite that causes visceral leishmaniasis, a severe form of leishmaniasis that affects vital organs. An important target for the treatment of this disease is the protein α-β tubulin, which was modeled in this paper and proposed as a target for the treatment of visceral leishmaniasis. Two classes of compounds were studied, dinitroanilines and oxadiazoles. According to the docking results, dinitroanilines interact better with the L loop domain and oxadiazoles interact better with the colchicine domain.
URI: http://repositorio.ufla.br/jspui/handle/1/28496
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