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|Title:||Effects of physical training on serum and pituitary growth hormone contents in diabetic rats|
Growth hormone and IGF
|Citation:||LEME, J. A. C. de A. et al. Effects of physical training on serum and pituitary growth hormone contents in diabetic rats. Pituitary, [S.l.], Dec. 2009.|
|Abstract:||The present study investigated the effects of moderate physical training on some of the parameters in the GH-IGF axis in experimental diabetic rats. Male Wistar rats were allocated into the following groups: sedentary control, trained control, sedentary diabetic, trained diabetic. Diabetes was induced by alloxan (32 mg/kg, b.w. iv). The physical training protocol consisted of 1 h swimming session/day, 5 days/week for 8 weeks supporting a load corresponding to 90% of maximal lactate steady state. After the experimental period, blood was collected to measure serum glucose, insulin, triglycerides, albumin, insulin-like growth factors-I (IGF-I), and growth hormone (GH). Pituitary gland was removed for GH quantification. Diabetes increased blood glucose and triglycerides and decreased insulin, IGF-I, serum and pituitary GH. Physical training decreased glucose and triglycerides, and also counteracted the reduction of serum IGF-I in diabetic rats. In conclusion, physical training recovered serum IGF-I showing no alteration of serum or pituitary GH levels.|
|Appears in Collections:||DEF - Artigos publicados em periódicos|
DME - Artigos publicados em periódicos
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