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metadata.artigo.dc.title: Effects of physical training on serum and pituitary growth hormone contents in diabetic rats
metadata.artigo.dc.creator: Leme, José Alexandre Curiacos de Almeida
Araújo, Michel Barbosa de
Moura, Leandro Pereira de
Gomes, Ricardo José
Moura, Rodrigo Ferreira de
Rogatto, Gustavo Puggina
Mello, Maria Alice Rostom de
Luciano, Eliete
metadata.artigo.dc.subject: Pituitary
Physical training
Growth hormone and IGF
metadata.artigo.dc.publisher: Springer Dec-2009
metadata.artigo.dc.identifier.citation: LEME, J. A. C. de A. et al. Effects of physical training on serum and pituitary growth hormone contents in diabetic rats. Pituitary, [S.l.], Dec. 2009.
metadata.artigo.dc.description.abstract: The present study investigated the effects of moderate physical training on some of the parameters in the GH-IGF axis in experimental diabetic rats. Male Wistar rats were allocated into the following groups: sedentary control, trained control, sedentary diabetic, trained diabetic. Diabetes was induced by alloxan (32 mg/kg, b.w. iv). The physical training protocol consisted of 1 h swimming session/day, 5 days/week for 8 weeks supporting a load corresponding to 90% of maximal lactate steady state. After the experimental period, blood was collected to measure serum glucose, insulin, triglycerides, albumin, insulin-like growth factors-I (IGF-I), and growth hormone (GH). Pituitary gland was removed for GH quantification. Diabetes increased blood glucose and triglycerides and decreased insulin, IGF-I, serum and pituitary GH. Physical training decreased glucose and triglycerides, and also counteracted the reduction of serum IGF-I in diabetic rats. In conclusion, physical training recovered serum IGF-I showing no alteration of serum or pituitary GH levels.
metadata.artigo.dc.language: en_US
Appears in Collections:DEF - Artigos publicados em periódicos
DSA - Artigos publicados em periódicos

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