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http://repositorio.ufla.br/jspui/handle/1/39045| Title: | Citocalasinas produzidas por Xylaria sp., um fungo endofítico de Piper aduncum (piperaceae) |
| Other Titles: | Cytochalasins produced by Xylaria sp., an endophytic fungus from Piper aduncum |
| Authors: | Silva, Geraldo H. Oliveira, Camila M. de Teles, Helder L. Bolzani, Vanderlan da Silva Araújo, Angela Regina Pfenning, Ludwig H. Young, Maria Claudia M. Costa-Neto, Claudio M. Haddad, Renato Eberlin, Marcos N. |
| Keywords: | Xylaria sp. Piper aduncum Endophytic fungus |
| Issue Date: | 2010 |
| Publisher: | Sociedade Brasileira de Química |
| Citation: | SILVA, G. H. et al. Citocalasinas produzidas por Xylaria sp., um fungo endofítico de Piper aduncum (piperaceae). Química Nova, São Paulo, v. 33, n. 10, p. 2038-2041, 2010. |
| Abstract: | A chemical study on the EtOAc extract produced by Xylaria sp., an endophytic fungus from Piper aduncum, resulted in the isolation of a new cytochalasin 1, along with five known 19,20-epoxycytochalasin D (2), C (3), N (4), Q (5), and R (6). The 1-6 were evaluated against the fungi C. cladosporioides and C. sphaerospermum and only 5 showed weak activity. The cytotoxicity in vitro against HeLA and CHO cells lines were investigated and the cytochalasins 2-4, and 6 showed a strong activity against HeLA. The DNAdamaging activity of 1-6 were also investigated against mutant strains of S. cerevisiae. |
| URI: | http://repositorio.ufla.br/jspui/handle/1/39045 |
| Appears in Collections: | DFP - Artigos publicados em periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| ARTIGO_Citocalasinas produzidas por Xylaria sp., um fungo endofítico de Piper aduncum (piperaceae).pdf | 194,32 kB | Adobe PDF | View/Open |
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