Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/40653
metadata.artigo.dc.title: Inappropriate antibiotic consumption as a possible cause of inflammatory storm and septic shock in patients diagnosed with Coronavirus Disease 2019 (COVID-19)
metadata.artigo.dc.creator: Hantoushzadeh, Sedigheh
Norooznezhad, Amir Hossein
metadata.artigo.dc.subject: COVID-19
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Septic shock
Antibiotics
Inflammation
metadata.artigo.dc.publisher: Elsevier
metadata.artigo.dc.date.issued: Apr-2020
metadata.artigo.dc.identifier.citation: HANTOUSHZADEH, S; NOROOZNEZHAD, A. H. Inappropriate antibiotic consumption as a possible cause of inflammatory storm and septic shock in patients diagnosed with Coronavirus Disease 2019 (COVID-19). Archives of Medical Research, [S.l.], Apr. 2020. No prelo.
metadata.artigo.dc.description.abstract: The novel coronavirus (SARS-CoV-2) infection which has been known as Coronavirus diseases 2019 (COVID-19) has become an endemic emergent situation by the World Health Organization. So far, no successful specific treatment has been found for this disease. As has been reported, most of non-survivor patients with COVID-19 (70%) had septic shock which was significantly higher than survived ones. Although the exact pathophysiology of septic shock in these patients is still unclear, it seems to be possible that part of it would be due to the administration of empiric antibiotics with inflammatory properties especially in the absence of bacterial infection. Herein, we have reviewed possible molecular pathways of septic shock in the patients who have received antibiotics with inflammatory properties which mainly is release of interleukin 1β (IL-1β), IL-6, and tumor necrosis factor α (TNF- α) through different routes. Altogether, we highly recommend clinicians to look after those antibiotics with anti-inflammatory activity for both empiric antibiotic therapy and reducing the inflammation to prevent septic shock in patients with diagnosed COVID-19.
metadata.artigo.dc.identifier.uri: https://www.sciencedirect.com/science/article/pii/S0188440920304094
http://repositorio.ufla.br/jspui/handle/1/40653
metadata.artigo.dc.language: en_US
Appears in Collections:FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)

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