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http://repositorio.ufla.br/jspui/handle/1/40905| Título: | Experimental hydrophilic reactivator: bisoxime with three positive charges |
| Palavras-chave: | Reactivator Oxime Nerve agent Docking study |
| Data do documento: | 2019 |
| Editor: | Springer |
| Citação: | KUCA, K. et al. Experimental hydrophilic reactivator: bisoxime with three positive charges. Chemical Papers, [S.l.], v. 73, p. 777-782, 2019. |
| Resumo: | Within this study, experimental hydrophilic acetylcholinesterase (AChE) reactivator was evaluated in vitro against selected nerve agents (cyclosarin, tabun, sarin, VX agent). High hydrophilicity of the reactivator is caused by the presence of three positive charges in its molecule. Quaternary moiety involved in the connecting chain can influence linker’s interaction with the inner of the AChE. For the detailed description of reactivator-AChE interaction, docking studies were performed on theoretical models constructed from the chrystallographic structure of Mus musculus AChE (MmAChE). |
| URI: | https://link.springer.com/article/10.1007/s11696-018-0612-6 http://repositorio.ufla.br/jspui/handle/1/40905 |
| Aparece nas coleções: | DQI - Artigos publicados em periódicos |
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