Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/41519
metadata.artigo.dc.title: Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections
metadata.artigo.dc.creator: Long, Quan-Xin
Tang, Xiao-Jun
Shi, Qiu-Lin
Li, Qin
Deng, Hai-Jun
Yuan, Jun
Hu, Jie-Li
Xu, Wei
Zhang, Yong
Lv, Fa-Jin
Su, Kun
Zhang, Fan
Gong, Jiang
Wu, Bo
Liu, Xia-Mao
Li, Jin-Jing
Qiu, Jing-Fu
Chen, Juan
Huang, Ai-Long
metadata.artigo.dc.subject: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
COVID-19
metadata.artigo.dc.publisher: Nature Publishing Group
metadata.artigo.dc.date.issued: 2020
metadata.artigo.dc.identifier.citation: LONG, Q. X. et al. Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections. Nature Medicine, [S.l.], 2020.
metadata.artigo.dc.description.abstract: The clinical features and immune responses of asymptomatic individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have not been well described. We studied 37 asymptomatic individuals in the Wanzhou District who were diagnosed with RT–PCR-confirmed SARS-CoV-2 infections but without any relevant clinical symptoms in the preceding 14 d and during hospitalization. Asymptomatic individuals were admitted to the government-designated Wanzhou People’s Hospital for centralized isolation in accordance with policy1. The median duration of viral shedding in the asymptomatic group was 19 d (interquartile range (IQR), 15–26 d). The asymptomatic group had a significantly longer duration of viral shedding than the symptomatic group (log-rank P = 0.028). The virus-specific IgG levels in the asymptomatic group (median S/CO, 3.4; IQR, 1.6–10.7) were significantly lower (P = 0.005) relative to the symptomatic group (median S/CO, 20.5; IQR, 5.8–38.2) in the acute phase. Of asymptomatic individuals, 93.3% (28/30) and 81.1% (30/37) had reduction in IgG and neutralizing antibody levels, respectively, during the early convalescent phase, as compared to 96.8% (30/31) and 62.2% (23/37) of symptomatic patients. Forty percent of asymptomatic individuals became seronegative and 12.9% of the symptomatic group became negative for IgG in the early convalescent phase. In addition, asymptomatic individuals exhibited lower levels of 18 pro- and anti-inflammatory cytokines. These data suggest that asymptomatic individuals had a weaker immune response to SARS-CoV-2 infection. The reduction in IgG and neutralizing antibody levels in the early convalescent phase might have implications for immunity strategy and serological surveys.
metadata.artigo.dc.identifier.uri: https://www.nature.com/articles/s41591-020-0965-6
http://repositorio.ufla.br/jspui/handle/1/41519
metadata.artigo.dc.language: en_US
Appears in Collections:FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)

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