Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/41525
metadata.artigo.dc.title: Use of hydroxychloroquine and interferon alpha-2b for the prophylaxis of COVID-19
metadata.artigo.dc.creator: Yang, Alexander
Yang, Charlotte
Yang, Bing
metadata.artigo.dc.subject: COVID-19
Hydroxychloroquine
Interferon alpha-2b
metadata.artigo.dc.publisher: Elsevier
metadata.artigo.dc.date.issued: Nov-2020
metadata.artigo.dc.identifier.citation: YANG, A.; YANG, C.; YANG, B. Use of hydroxychloroquine and interferon alpha-2b for the prophylaxis of COVID-19. Medical Hypotheses, [S.l.], v. 144, Nov. 2020.
metadata.artigo.dc.description.abstract: The ongoing pandemic of COVID-19 infection demands efforts to reduce spread. In order to eradicate an infectious disease, a method of prevention with low social cost is the most effective way. While we wait for new therapies and a vaccine, we are proposing a solution based on the existing knowledge in biomedical sciences. Here we propose to use low doses of hydroxychloroquine (50–100 mg daily orally) and intranasal interferon alpha-2b (IFN α-2b) spray (0.5 × 106 IU twice daily) for the prophylaxis of COVID-19. Although there are ongoing clinical trials to test the efficacy of hydroxychloroquine for prophylaxis, there has not been any proposal to test the efficacy of IFN α-2b together with hydroxychloroquine to increase protection against COVID-19. Since the two act on two different mechanisms, we strongly believe that the two could have additive effects in prophylaxis against COVID-19. We recommend using a randomized control study to prove efficacy and safety.
metadata.artigo.dc.identifier.uri: https://www.sciencedirect.com/science/article/pii/S030698772030709X
http://repositorio.ufla.br/jspui/handle/1/41525
metadata.artigo.dc.language: en_US
Appears in Collections:FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)

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