Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/45973
metadata.artigo.dc.title: Network analysis and molecular mapping for SARS-CoV-2 to reveal drug targets and repurposing of clinically developed drugs
metadata.artigo.dc.creator: More, Shweta A.
Patil, Akshay S.
Sakle, Nikhil S.
Mokale, Santosh N.
metadata.artigo.dc.subject: COVID-19
Coronavirus
SARS-CoV-2
Drug repurposing
Molecular docking
Reaproveitamento de drogas
metadata.artigo.dc.publisher: Elsevier
metadata.artigo.dc.date.issued: 2020
metadata.artigo.dc.identifier.citation: MORE, S. A. et al. Network analysis and molecular mapping for SARS-CoV-2 to reveal drug targets and repurposing of clinically developed drugs. Virology, [S. l.], 2020. DOI: https://doi.org/10.1016/j.virol.2020.12.006.
metadata.artigo.dc.description.abstract: Novel coronavirus (SARS–CoV–2), turned out to be a global pandemic with unstoppable morbidity and mortality rate. However, till date there is no effective treatment found against SARS–CoV–2. We report on the major in–depth molecular and docking analysis by using antiretroviral (Lopinavir and ritonavir), antimalarial (Hydroxychloroquine), antibiotics (Azithromycin), and dietary supplements (Vitamin C and E) to provide new insight into drug repurposing molecular events involved in SARS–CoV–2. We constructed three drug–target–pathways–disease networks to predict the targets and drugs interactions as well as important pathways involved in SARS–CoV–2. The results suggested that by using the combination of Lopinavir, Ritonavir along with Hydroxychloroquine and Vitamin C may turned out to be the effective line of treatment for SARS–CoV–2 as it shows the involvement of PARP–1, MAPK–8, EGFR, PRKCB, PTGS–2, and BCL–2. Gene ontology biological process analysis further confirmed multiple viral infection–related processes (P < 0.001), including viral life cycle, modulation by virus, C–C chemokine receptor activity, and platelet activation. KEGG pathway analysis involves multiple pathways (P < 0.05), including FoxO, GnRH, ErbB, Neurotrophin, Toll–like receptor, IL–17, TNF, Insulin, HIF–1, JAK–STAT, Estrogen, NF–kappa, Chemokine, VEGF, and Thyroid hormone signaling pathway in SARS–CoV–2. Docking study was carried out to predict the molecular mechanism Thus, the potential drug combinations could reduce viral infectivity, viral replication, and abnormal host inflammatory responses and may be useful for multi–target drugs against SARS–CoV–2.
metadata.artigo.dc.identifier.uri: https://www.sciencedirect.com/science/article/pii/S0042682220302464#!
http://repositorio.ufla.br/jspui/handle/1/45973
metadata.artigo.dc.language: en_US
Appears in Collections:FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)

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