Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/46784
Title: Nitrogen Catabolite Repression in members of Paracoccidioides complex
Keywords: Nitrogen metabolism
Paracoccidioides spp.
AreA GATA transcription factor
Three-dimensional structure
Nitrogênio - Metabolismo
Paracoccidioidomicose
Fatores de transcrição GATA
Estrutura tridimensional
Issue Date: Dec-2020
Publisher: Elsevier
Citation: CRUZ-LEITE, V. R. M. et al. Nitrogen Catabolite Repression in members of Paracoccidioides complex. Microbial Pathogenesis, [S. I.], v. 149, Dec. 2020. DOI: https://doi.org/10.1016/j.micpath.2020.104281.
Abstract: Paracoccidioides complex is a genus that comprises pathogenic fungi which are responsible by systemic disease Paracoccidioidomycosis. In host tissues, pathogenic fungi need to acquire nutrients in order to survive, making the uptake of nitrogen essential for their establishment and dissemination. Nitrogen utilization is employed by the alleviation of Nitrogen Catabolite Repression (NCR) which ensures the use of non-preferential or alternative nitrogen sources when preferential sources are not available. NCR is controlled by GATA transcription factors which act through GATA binding sites on promoter regions in NCR-sensitive genes. This process is responsible for encoding proteins involved with the scavenge, uptake and catabolism of a wide variety of non-preferential nitrogen sources. In this work, we predict the existence of AreA GATA transcription factor and feature the zinc finger domain by three-dimensional structure in Paracoccidioides. Furthermore, we demonstrate the putative genes involved with NCR response by means of in silico analysis. The gene expression profile under NCR conditions was evaluated. Demonstrating that P. lutzii supported transcriptional regulation and alleviated NCR in non-preferential nitrogen-dependent medium. The elucidation of NCR in members of Paracoccidioides complex will provide new knowledge about survival, dissemination and virulence for these pathogens with regard to nitrogen-scavenging strategies in the interactions of host-pathogens.
URI: https://doi.org/10.1016/j.micpath.2020.104281
http://repositorio.ufla.br/jspui/handle/1/46784
Appears in Collections:DBI - Artigos publicados em periódicos

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