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Title: K-mer applied in Mycobacterium tuberculosis genome cluster analysis
Other Titles: K-mer aplicado na análise de agrupamento de genomas de Mycobacterium tuberculosis
Keywords: Mycobacterium tuberculosis
DNA word frequency
Similar sequences
Frequência de palavras do DNA
Sequências similares
Issue Date: 2024
Publisher: Instituto Internacional de Ecologia
Citation: FERREIRA, L. M.; SÁFADI, T.; FERREIRA, J. L. K-mer applied in Mycobacterium tuberculosis genome cluster analysis. Brazilian Journal of Biology, São Carlos, v. 84, e258258, 2022. DOI: 10.1590/1519-6984.258258.
Abstract: According to studies carried out, approximately 10 million people developed tuberculosis in 2018. Of this total, 1.5 million people died from the disease. To study the behavior of the genome sequences of Mycobacterium tuberculosis (MTB), the bacterium responsible for the development of tuberculosis (TB), an analysis was performed using k-mers (DNA word frequency). The k values ranged from 1 to 10, because the analysis was performed on the full length of the sequences, where each sequence is composed of approximately 4 million base pairs, k values above 10, the analysis is interrupted, as consequence of the program's capacity. The aim of this work was to verify the formation of the phylogenetic tree in each k-mer analyzed. The results showed the formation of distinct groups in some k-mers analyzed, taking into account the threshold line. However, in all groups, the multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains remained together and separated from the other strains.
Appears in Collections:DES - Artigos publicados em periódicos
DEX - Artigos publicados em periódicos

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