In silico study of leishmania donovani α-β tubulin and inhibitors

Assis, Tamiris M.; Mancini, Daiana T.; Ramalho, Teodorico C.; Cunha, Elaine F. F. da

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Campo DC	Valor	Idioma
dc.creator	Assis, Tamiris M.	-
dc.creator	Mancini, Daiana T.	-
dc.creator	Ramalho, Teodorico C.	-
dc.creator	Cunha, Elaine F. F. da	-
dc.date.accessioned	2018-01-26T16:03:40Z	-
dc.date.available	2018-01-26T16:03:40Z	-
dc.date.issued	2014	-
dc.identifier.citation	ASSIS, T. M. et al. In silico study of leishmania donovani α-β tubulin and inhibitors. Journal of Chemistry, [S. l.], v. 2014, p. 1-8, 2014. doi: http://dx.doi.org/10.1155/2014/492579.	pt_BR
dc.identifier.uri	http://repositorio.ufla.br/jspui/handle/1/28496	-
dc.description.abstract	Leishmania donovani is a parasite that causes visceral leishmaniasis, a severe form of leishmaniasis that affects vital organs. An important target for the treatment of this disease is the protein α-β tubulin, which was modeled in this paper and proposed as a target for the treatment of visceral leishmaniasis. Two classes of compounds were studied, dinitroanilines and oxadiazoles. According to the docking results, dinitroanilines interact better with the L loop domain and oxadiazoles interact better with the colchicine domain.	pt_BR
dc.language	en_US	pt_BR
dc.publisher	Hindawi Publishing Corporation	pt_BR
dc.rights	acesso aberto	pt_BR
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.source	Journal of Chemistry	pt_BR
dc.subject	Visceral leishmaniasis	pt_BR
dc.subject	Dinitroanilines	pt_BR
dc.subject	Oxadiazoles	pt_BR
dc.subject	Leishmaniose visceral	pt_BR
dc.subject	Dinitroanilinas	pt_BR
dc.title	In silico study of leishmania donovani α-β tubulin and inhibitors	pt_BR
dc.type	Artigo	pt_BR
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