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http://repositorio.ufla.br/jspui/handle/1/28496| Title: | In silico study of leishmania donovani α-β tubulin and inhibitors |
| Keywords: | Visceral leishmaniasis Dinitroanilines Oxadiazoles Leishmaniose visceral Dinitroanilinas |
| Issue Date: | 2014 |
| Publisher: | Hindawi Publishing Corporation |
| Citation: | ASSIS, T. M. et al. In silico study of leishmania donovani α-β tubulin and inhibitors. Journal of Chemistry, [S. l.], v. 2014, p. 1-8, 2014. doi: http://dx.doi.org/10.1155/2014/492579. |
| Abstract: | Leishmania donovani is a parasite that causes visceral leishmaniasis, a severe form of leishmaniasis that affects vital organs. An important target for the treatment of this disease is the protein α-β tubulin, which was modeled in this paper and proposed as a target for the treatment of visceral leishmaniasis. Two classes of compounds were studied, dinitroanilines and oxadiazoles. According to the docking results, dinitroanilines interact better with the L loop domain and oxadiazoles interact better with the colchicine domain. |
| URI: | http://repositorio.ufla.br/jspui/handle/1/28496 |
| Appears in Collections: | DQI - Artigos publicados em periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| ARTIGO_In silico study of leishmania donovani α-β tubulin and inhibitors.pdf | 2,41 MB | Adobe PDF | View/Open |
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