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|Título :||Assessing non-additive effects in GBLUP model|
|Autor:||Vieira, I. C.|
Santos, J. P. R. dos
Pires, L. P. M.
Lima, B. M.
Gonçalves, F. M. A.
|Publicador:||Fundação de Pesquisas Científicas de Ribeirão Preto (FUNPEC-RP)|
|Data da publicação:||10-Mai-2017|
|Referência:||VIEIRA, I. C. et al. Assessing non-additive effects in GBLUP model. Genetics and Molecular Research, Ribeirão Preto, v. 16, n. 2, 2017.|
|Abstract:||Understanding non-additive effects in the expression of quantitative traits is very important in genotype selection, especially in species where the commercial products are clones or hybrids. The use of molecular markers has allowed the study of non-additive genetic effects on a genomic level, in addition to a better understanding of its importance in quantitative traits. Thus, the purpose of this study was to evaluate the behavior of the GBLUP model in different genetic models and relationship matrices and their influence on the estimates of genetic parameters. We used real data of the circumference at breast height in Eucalyptus spp and simulated data from a population of F2. Three commonly reported kinship structures in the literature were adopted. The simulation results showed that the inclusion of epistatic kinship improved prediction estimates of genomic breeding values. However, the non-additive effects were not accurately recovered. The Fisher information matrix for real dataset showed high collinearity in estimates of additive, dominant, and epistatic variance, causing no gain in the prediction of the unobserved data and convergence problems. Estimates presented differences of genetic parameters and correlations considering the different kinship structures. Our results show that the inclusion of non-additive effects can improve the predictive ability or even the prediction of additive effects. However, the high distortions observed in the variance estimates when the Hardy-Weinberg equilibrium assumption is violated due to the presence of selection or inbreeding can converge at zero gains in models that consider epistasis in genomic kinship.|
|Aparece nas coleções:||DBI - Artigos publicados em periódicos|
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