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|metadata.artigo.dc.title:||Cytogenotoxic Effects of Spent Pot Liner (SPL) and its main components on human leukocytes and meristematic cells of Allium cepa|
|metadata.artigo.dc.creator:||Palmieri, Marcel José|
Andrade-Vieira, Larissa Fonseca
Trento, Marcus Vinícius Cardoso
Eleutério, Mateus William de Faria
Davide, Lisete Chamma
Cell cycle alterations
|metadata.artigo.dc.identifier.citation:||PALMIERI, M. J. et al. Cytogenotoxic effects of Spent Pot Liner (SPL) and its main components on human leukocytes and meristematic cells of Allium cepa. Water, Air and Soil Pollution, [S.l.], v. 227, n. 5, May 2016.|
|metadata.artigo.dc.description.abstract:||The Spent Pot Liner (SPL) is a toxic solid waste from the aluminum industry. The genotoxic potential of SPL and its main chemical components (fluoride, cyanide, and aluminum) were evaluated on vegetal (Allium cepa L. system test) and human cells (comet assay) in the present study. Meristematic cells from A. cepa submitted to the treatments presented a reduction in the mitotic index (MI) and an increase in the frequency of chromosome alterations (CA). The SPL treatment reduced MI in 50 % when compared to the negative control. In addition, there were significant reductions in MI on the cyanide and aluminum treatments. All frequencies of chromosome alterations observed to the treatments were statistically different from control, and cyanide was the most cytogenotoxic component. The exposed cells to the treatments also increased the frequency of condensed nuclei. The comet assay on human leukocytes demonstrated that all treatments induced DNA fragmentation. Fluoride and SPL showed similar damages to the positive control (doxorubicin, UA = 259.7) and higher than the negative control (CaCl2 0.01 M, UA = 16.5). The aluminum induced intermediary damage, and the cyanide was responsible for minor damage. In conclusion, both SPL and its main components presented genotoxic and mutagenic potential on evaluated cells. Fluoride was the main genotoxic component for human leukocytes while cyanide leads the higher alterations for A. cepa meristematic cells. Thus, the storage and discard of this residue should be regulated and supervised more closely in order to reduce the risk of environmental pollution and its contact with human.|
|Appears in Collections:||DBI - Artigos publicados em periódicos|
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