Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/31442
metadata.artigo.dc.title: Endocrine cells producing peptide hormones in the intestine of Nile tilapia: distribution and effects of feeding and fasting on the cell density
metadata.artigo.dc.creator: Pereira, Raquel Tatiane
Freitas, Thaiza Rodrigues de
Oliveira, Izabela Regina Cardoso de
Costa, Leandro Santos
Vigliano, Fabricio Andrés
Rosa, Priscila Vieira
metadata.artigo.dc.subject: Cholecystokinin
Gastrin
Neuropeptide Y
Calcitonin gene-related peptide
Immunohistochemistry
Fish
metadata.artigo.dc.publisher: Springer
metadata.artigo.dc.date.issued: Oct-2017
metadata.artigo.dc.identifier.citation: PEREIRA, R. T. et al. Endocrine cells producing peptide hormones in the intestine of Nile tilapia: distribution and effects of feeding and fasting on the cell density. Fish Physiology and Biochemistry, [S.l.], v. 43, n. 5, p. 1399–1412, Oct. 2017.
metadata.artigo.dc.description.abstract: Endocrine cells (ECs) act as a luminal surveillance system responding to either the presence or absence of food in the gut through the secretion of peptide hormones. The aim of this study was to analyze the effects of feeding and fasting on the EC peptide-specific distribution along the intestine of Nile tilapia. We assessed the density of ECs producing gastrin (GAS), cholecystokinin-8 (CCK-8), neuropeptide Y (NPY), and calcitonin gene-related peptide (CGRP) in nine segments of the intestine using immunohistochemistry. Our results show that ECs immunoreactive to CCK-8, GAS, NPY, and CGRP can be found along all the intestinal segments sampled, from the midgut to hindgut, although differences in their distribution along the gut were observed. Regarding nutrient status, we found that the anterior segments of the midgut seem to be the main site responding to luminal changes in Nile tilapia. The NPY+ and CGRP+ EC densities increased in the fasted group, while the amount of CCK-8+ ECs were higher in the fed group. No effects of fasting or feeding were found in the GAS+ EC densities. Changes in ECs density were found only at the anterior segments of the intestine which may be due to the correlation between vagus nerve anatomy, EC location, and peptide turnover. Lastly, ECs may need to be considered an active cell subpopulation that may adapt and respond to different nutrient status as stimuli. Due to the complexity of the enteroendocrine system and its importance in fish nutrition, much remains to be elucidated and it deserves closer attention.
metadata.artigo.dc.identifier.uri: https://link.springer.com/article/10.1007/s10695-017-0380-1
http://repositorio.ufla.br/jspui/handle/1/31442
metadata.artigo.dc.language: en_US
Appears in Collections:DES - Artigos publicados em periódicos
DZO - Artigos publicados em periódicos

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