Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/31936
Title: New cytotoxic furan from the marine sediment-derived fungi Aspergillus niger
Keywords: Marine-derived fungi
Aspergillus niger
Furan derivative
Cytotoxic activity
Fungos derivados dos marinhos
Derivado de furano
Atividade citotóxica
Issue Date: 2017
Publisher: Taylor & Francis
Citation: UCHOA, P. K. S. et al. New cytotoxic furan from the marine sediment-derived fungi Aspergillus niger. Natural Product Research, Abingdon, v. 31, n. 22, p. 2599-2603, 2017.
Abstract: A fungal strain of Aspergillus niger was recovered from sediments collected in the Northeast coast of Brazil (Pecém’s offshore port terminal). Cultivation in different growth media yielded a new ester furan derivative, 1, along with malformin A1, malformin C, cyclo (trans-4-hydroxy-L-Pro-L-Leu), cyclo (trans-4-hydroxy-L-Pro-L-Phe), cyclo (L-Pro-L-Leu), cyclo (L-Pro-L-Phe), pseurotin D, pseurotin A, chlovalicin, cyclo (L-Pro-L-Tyr) and cyclo (L-Pro-L-Val). Compound 1 was cytotoxic against HCT-116 cell line, showing IC50 = 2.9 μg/mL (CI 95% from 1.8 to 4.7 μg/mL).
URI: https://www.tandfonline.com/doi/abs/10.1080/14786419.2017.1283499?journalCode=gnpl20
http://repositorio.ufla.br/jspui/handle/1/31936
Appears in Collections:DFP - Artigos publicados em periódicos

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