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http://repositorio.ufla.br/jspui/handle/1/32518| Title: | Phytochemical study and anti-inflammatory effect of Psychotria stenocalyx (Rubiaceae) |
| Keywords: | Psychotria stenocalyx Antiinflammatory Monoterpene indole alkaloids Antiinflamatório Alcalóides indólicos monoterpénicos |
| Issue Date: | Apr-2017 |
| Publisher: | ScopeMed |
| Citation: | QUEIROZ, G. S. et al. Phytochemical study and anti-inflammatory effect of Psychotria stenocalyx (Rubiaceae). Journal of Applied Pharmaceutical Science, [S. l.], v. 7, n. 4, p. 168-173, Apr. 2017. |
| Abstract: | In this study, an in vivo anti-inflammatory assay was conducted on Psychotria stenocalyx ethanol extract of leaves, evaluating this effect on cell migration and exudate formation in a murine carrageenan-induced model of pleurisy. The extract showed the optimum dose, at 400 mg/kg, inhibiting cellular and vascular parameters: total leucocytes due to polymorphonuclear migration and exudate formation (p < 0.01). A phytochemical study was conducted using the hyphenated techniques HPLC-DAD-SPE/NMR and HPLC-DAD-ESI-TOF-HRMS, in which seven monoterpene indole alkaloids were identified: lyaloside 1, (E)-O-(6&′)-cinnamoyl-4”-hydroxy-3”,5”-dimethoxy-lyaloside 2, strictosamide 3, pauridianthoside 4, vallesiachotamine lactone 5, E-vallesiachotamine 6 and Z-vallesiachotamine 7, in the alkaloid fraction, obtained by an acid-base extraction on P. stenocalyx crude extract. This is the first study developed with this species. |
| URI: | http://repositorio.ufla.br/jspui/handle/1/32518 |
| Appears in Collections: | DQI - Artigos publicados em periódicos |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| ARTIGO_Phytochemical study and anti-inflammatory effect of Psychotria stenocalyx (Rubiaceae).pdf | 672,66 kB | Adobe PDF | View/Open |
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