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http://repositorio.ufla.br/jspui/handle/1/34084| Title: | Crystal structure of two new polymeric copper(II) complexes active against Trypanosoma cruzi |
| Keywords: | Copper(II) complexes Crystal structure Trypanosoma cruzi Cytotoxic activity |
| Issue Date: | Nov-2018 |
| Citation: | PAIXÃO, D. A. et al. Crystal structure of two new polymeric copper(II) complexes active against Trypanosoma cruzi. Journal of Saudi Chemical Society, [S.l.], v. 22, n. 7, p. 809-815, Nov. 2018. |
| Abstract: | We report here the characterization of two new polymeric copper(II) complexes containing 2-chlorobenzhydrazide (2-CH) and two N,N-donor ligands, namely, 1,10-phenanthroline (phen) and 4-4′-dimethoxy-2-2′-bipyridine (dmb). The structure of a new polymeric copper(II) complex in which a perchlorate anion acts as a bridge ligand is discussed in detail. In both complexes, spectral data reveals a bidentate coordination mode for hydrazide, perchlorate and N,N-donor ligand. These metal complexes and their free ligands were evaluated for their trypanocidal and cytotoxic activities and the complex with 1,10-phenanthroline has been much more active than benznidazole, a drug used in the treatment of Chagas disease. |
| URI: | https://www.sciencedirect.com/science/article/pii/S1319610318300036 http://repositorio.ufla.br/jspui/handle/1/34084 |
| Appears in Collections: | DQI - Artigos publicados em periódicos |
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