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Title: Growth factors and glucose homeostasis in diabetic rats: effects of exercise training
Keywords: Diabetes
Glucose homeostasis
Insulin-like growth factor-I
Issue Date: Jun-2009
Publisher: Wiley Online Library
Citation: GOMES, R. J. et al. Growth factors and glucose homeostasis in diabetic rats: effects of exercise training. Cell Biochemistry and Function, [S.l.], v. 27, n. 4, p. 199-204, June 2009.
Abstract: To investigate the alterations of glucose homeostasis and variables of the insulin‐like growth factor‐1 (IGF‐1) growth system in sedentary and trained diabetic (TD) rats, Wistar rats were divided into sedentary control (SC), trained control (TC), sedentary diabetic (SD), and TD groups. Diabetes was induced by Alloxan (35 mg kg−1 b.w.). Training program consisted of swimming 5 days week−1, 1 h day−1, during 8 weeks. Rats were sacrificed and blood was collected for determinations of serum glucose, insulin, growth hormone (GH), IGF‐1, and IGF binding protein‐3 (IGFBP‐3). Muscle and liver were removed to evaluate glycogen content. Cerebellum was extracted to determinate IGF‐1 content. Diabetes decreased serum GH, IGF‐1, IGFBP‐3, liver glycogen, and cerebellum IGF‐1 peptide content in baseline condition. Physical training recovered liver glycogen and increased serum and cerebellum IGF‐1 peptide in diabetic rats. Physical training induces important metabolic and hormonal alterations that are associated with an improvement in glucose homeostasis and serum and cerebellum IGF‐1 concentrations.
Appears in Collections:DEF - Artigos publicados em periódicos
DME - Artigos publicados em periódicos

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