Antispasmodic effect of Ocimum selloi essential oil on the guinea-pig ileum

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Título:	Antispasmodic effect of Ocimum selloi essential oil on the guinea-pig ileum
Palavras-chave:	Ocimum selloi Spasmolytic Methyl chavicol Espasmolítico Metil chavicol
Data do documento:	2015
Editor:	Taylor & Francis
Citação:	SOUZA, S. D. F. et al. Antispasmodic effect of Ocimum selloi essential oil on the guinea-pig ileum. Natural Product Research, Abingdon, v. 29, n. 22, p. 2125-2128, 2015.
Resumo:	Ocimum selloi is an herbal species popularly used in Brazil as antispasmodic. Herein, we report the antispasmodic effect of O. selloi essential oil (OS) in segments of guinea-pig ileum. OS did not reduce the tonus of the ileum. In contrast, OS reduced the contraction induced by carbachol (100 μM), BaCl2 (0.03 M) and low- and high-K+ concentrations (25 and 60 mM, respectively). OS shifted the concentration–response curve for calcium to the right in a parallel manner. GC/MS analysis showed that OS consists mostly of methyl chavicol (97.57%). These results suggest that OS antispasmodic effect is mediated through calcium channel blockade. In addition, OS effect and mode of action could be accounted for methyl chavicol.
URI:	https://www.tandfonline.com/doi/full/10.1080/14786419.2014.989392 http://repositorio.ufla.br/jspui/handle/1/38335
Aparece nas coleções:	DAG - Artigos publicados em periódicos

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