Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/38919
Title: Systemic administration of a nanoemulsion with tributyrin reduces inflammation in experimental colitis
Keywords: Butyrate
Colitis
Fatty acid
Inflammatory bowel disease
Tributyrin
Butirato
Ácidos graxos
Doença inflamatória intestinal
Issue Date: Feb-2016
Publisher: Wiley
Citation: LEONEL, A. J. et al. Systemic administration of a nanoemulsion with tributyrin reduces inflammation in experimental colitis. European Journal of Lipid Science and Technology, [S. l.], v. 118, n. 2, p. 157-164, Feb. 2016.
Abstract: Tributyrin (TBT) is a triacylglycerol formed by three molecules of butyrate that is able to improve colonic mucosal lesions and inflammation when given orally or as an enema. The effects of systemic TBT administration in inflammatory bowel disease (IBD) have been less well studied. We prepared a nanoemulsion containing tributyrin (nTBT) and studied its effects on a model of dextran sodium sulfate (DSS)‐induced colitis. Mice were kept in the experiment for 15 days. Animals in the Colitis group received DSS (2.5% in their drinking water), whereas Control mice received only water during the last 7 experimental days. Animals were injected intraperitoneally (IP) with a nanoemulsion lacking TBT (Control and Colitis group) or containing TBT (Control nTBT and nTBT‐Colitis) every other day for 15 days. Colonic mucosal damage and cytokine concentration were assessed by histopathological score and ELISA, respectively. Inflammatory infiltrates were assessed by enzymatic assay, and leukocyte rolling and adhesion in the colonic circulation were determined by intravital microscopy. Results revealed that the colonic architecture was not modified by nTBT administration. However, the colons of nTBT‐Colitis mice presented reduced eosinophilic and neutrophilic infiltration associated with increased TGF‐β concentrations compared to those of the Colitis group. Leukocyte rolling and adhesion were reduced in the nTBT‐Colitis group, suggesting a systemic anti‐inflammatory effect of nTBT. In conclusion, our results show that nTBT administered intraperitoneally is effective in reducing DSS‐induced inflammation, whereas the trophic effects described with oral or local administration of TBT were not present when it was injected systemically.
URI: https://onlinelibrary.wiley.com/doi/full/10.1002/ejlt.201400359
http://repositorio.ufla.br/jspui/handle/1/38919
Appears in Collections:DNU - Artigos publicados em periódicos

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