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dc.creatorZhou, Peng-
dc.creatorYang, Xing-Lou-
dc.creatorWang, Xian-Guang-
dc.creatorHu, Ben-
dc.creatorZhang, Lei-
dc.creatorZhang, Wei-
dc.creatorSi, Hao-Rui-
dc.creatorZhu, Yan-
dc.creatorLi, Bei-
dc.creatorHuang, Chao-Lin-
dc.creatorChen, Hui-Dong-
dc.creatorChen, Jing-
dc.creatorLuo, Yun-
dc.creatorGuo, Hua-
dc.creatorJiang, Ren-Di-
dc.creatorLiu, Mei-Qin-
dc.creatorChen, Ying-
dc.creatorShen, Xu-Rui-
dc.creatorWang, Xi-
dc.creatorZheng, Xiao-Shuang-
dc.creatorZhao, Kai-
dc.creatorChen, Quan-Jiao-
dc.creatorDeng, Fei-
dc.creatorLiu, Lin-Lin-
dc.creatorYan, Bing-
dc.creatorZhan, Fa-Xian-
dc.creatorWang, Yan-Yi-
dc.creatorXiao, Geng-Fu-
dc.creatorShi, Zheng-Li-
dc.date.accessioned2020-03-26T11:55:17Z-
dc.date.available2020-03-26T11:55:17Z-
dc.date.issued2020-
dc.identifier.citationZHOU, P. et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, London, v. 579, p. 270-273, 2020.pt_BR
dc.identifier.urihttp://repositorio.ufla.br/jspui/handle/1/39411-
dc.description.abstractSince the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1,2,3,4. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans5,6,7. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor—angiotensin converting enzyme II (ACE2)—as SARS-CoV.pt_BR
dc.languageen_USpt_BR
dc.publisherSpringer Naturept_BR
dc.rightsacesso abertopt_BR
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourceNaturept_BR
dc.subjectCoronaviruspt_BR
dc.subjectSevere acute respiratory syndromept_BR
dc.subjectPathogenic viruspt_BR
dc.subjectSíndrome respiratória aguda gravept_BR
dc.subjectVírus patogênicospt_BR
dc.titleA pneumonia outbreak associated with a new coronavirus of probable bat originpt_BR
dc.typeArtigopt_BR
Aparece nas coleções:FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)

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