Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/39411
metadata.artigo.dc.title: A pneumonia outbreak associated with a new coronavirus of probable bat origin
metadata.artigo.dc.creator: Zhou, Peng
Yang, Xing-Lou
Wang, Xian-Guang
Hu, Ben
Zhang, Lei
Zhang, Wei
Si, Hao-Rui
Zhu, Yan
Li, Bei
Huang, Chao-Lin
Chen, Hui-Dong
Chen, Jing
Luo, Yun
Guo, Hua
Jiang, Ren-Di
Liu, Mei-Qin
Chen, Ying
Shen, Xu-Rui
Wang, Xi
Zheng, Xiao-Shuang
Zhao, Kai
Chen, Quan-Jiao
Deng, Fei
Liu, Lin-Lin
Yan, Bing
Zhan, Fa-Xian
Wang, Yan-Yi
Xiao, Geng-Fu
Shi, Zheng-Li
metadata.artigo.dc.subject: Coronavirus
Severe acute respiratory syndrome
Pathogenic virus
Síndrome respiratória aguda grave
Vírus patogênicos
metadata.artigo.dc.publisher: Springer Nature
metadata.artigo.dc.date.issued: 2020
metadata.artigo.dc.identifier.citation: ZHOU, P. et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, London, v. 579, p. 270-273, 2020.
metadata.artigo.dc.description.abstract: Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1,2,3,4. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans5,6,7. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor—angiotensin converting enzyme II (ACE2)—as SARS-CoV.
metadata.artigo.dc.identifier.uri: http://repositorio.ufla.br/jspui/handle/1/39411
metadata.artigo.dc.language: en_US
Appears in Collections:FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)

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