The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

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Título :	The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade
Autor:	Coutard, B. Valle, C. Lamballerie, X. de Canard, B. Seidah, N. G. Decroly, E.
Palavras-chave:	2019-nCoV Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Spike protein Maturation protease Furin Antivirals
Publicador:	Elsevier
Data da publicação:	Abr-2020
Referência:	COUTARD, B. et al. The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade. Antiviral Research, [S.l.], v. 176, Apr. 2020.
Abstract:	In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.
URI:	http://www.sciencedirect.com/science/article/pii/S0166354220300528 http://repositorio.ufla.br/jspui/handle/1/40605
Idioma:	en_US
Aparece nas coleções:	FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)

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