Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/40680
metadata.artigo.dc.title: Prospection of enzyme modulators in aqueous and ethanolic extracts of Lippia sidoides leaves: genotoxicity, digestion, inflammation, and hemostasis
metadata.artigo.dc.creator: Braga, Mariana Aparecida
Abreu, Tatiane Silva de
Trento, Marcus Vinicius Cardoso
Machado, Gustavo Henrique Andrade
Pereira, Luciana Lopes Silva
Simão, Anderson Assaid
Marcussi, Silvana
metadata.artigo.dc.subject: Lippia sidoides
Medicinal chemistry
Phospholipase inhibitors
Proteases inhibitors
Digestive enzymes inhibitors
Antigenotoxic compounds
Biological activity
Química Medicinal
Inibidores da fosfolipase
Inibidores de proteases
Inibidores das enzimas digestivas
Atividades antigenotóxicas
Atividade biológica
metadata.artigo.dc.publisher: Wiley Online Library
metadata.artigo.dc.date.issued: Mar-2019
metadata.artigo.dc.identifier.citation: BRAGA, M. A. et al. Prospection of enzyme modulators in aqueous and ethanolic extracts of Lippia sidoides leaves: genotoxicity, digestion, inflammation, and hemostasis. Chemistry & Biodiversity, Zurich, v. 16, n. 3, Mar. 2019. DOI: 10.1002/cbdv.201800558
metadata.artigo.dc.description.abstract: The aqueous and ethanolic extracts of Lippia sidoides Cham. were chemically characterized and tested for their action on enzymes involved in processes such as inflammation, blood coagulation, and digestion. Both extracts potentiated the activity of phospholipases A2 present in the venom of Bothrops atrox in 12 % and completely inhibited the hemolysis induced by B. jararacussu and B. moojeni venoms in the proportions between 1 : 0.5 and 1 : 5 (venom/extracts (w/w)). They inhibited the thrombolysis induced by B. moojeni (10 to 25 %), potentiated the thrombolysis induced by the Lachesis muta muta venom (30 to 80 %), prolonged the coagulation time induced by B. moojeni and L. muta muta venoms, and presented antigenotoxic action. Both extracts reduced the activity of α‐glycosidases, the aqueous extract inhibited lipases, and the ethanolic extract inhibited α‐amylases. The results demonstrate the modulatory action of the extracts on proteases, phospholipases, and digestive enzymes. In addition, the rich phenolic composition of these extracts highlights their potential for nutraceutical use.
metadata.artigo.dc.identifier.uri: https://onlinelibrary.wiley.com/doi/full/10.1002/cbdv.201800558
http://repositorio.ufla.br/jspui/handle/1/40680
metadata.artigo.dc.language: en
Appears in Collections:DQI - Artigos publicados em periódicos

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