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http://repositorio.ufla.br/jspui/handle/1/40770| Title: | A new complex of Palladium(II) with 2-furoic hydrazide: synthesis, characterization, theoretical calculations and biological studies |
| Keywords: | Palladium complexes Hydrazides Hydrazones DFT Density functional theory Antibacterial activity |
| Issue Date: | 2013 |
| Publisher: | Croatian Chemical Society |
| Citation: | SOUZA, G. D. de et al. A new complex of Palladium(II) with 2-furoic hydrazide: synthesis, characterization, theoretical calculations and biological studies. Croatica Chemica Acta, [S.l.], v. 86, n. 2, p. 201-206, 2013. DOI: 10.5562/cca2151. |
| Abstract: | A new complex of palladium was isolated with 2-furoic hydrazide (FH) and characterized by spectroscopic methods. The results show that the ligand is coordinated to palladium by the basic nitrogen of NH2 group and has a general structure of type cis-[Pd(FH)2Cl2]. The structure of palladium(II) complex was optimized and theoretical data show good agreement with the experimental results. The cytotoxic activity was evaluated in a chronic myelogenous leukemia cell line, which revealed that the compound is less active than cisplatin or carboplatin. At 300 g mL−1, the complex presented antimicrobial activity more efficient than ampicillin, chloranfenicol and kanamicyn. |
| URI: | https://hrcak.srce.hr/105586 http://repositorio.ufla.br/jspui/handle/1/40770 |
| Appears in Collections: | DQI - Artigos publicados em periódicos |
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