Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/40825
Title: Synthesis, characterization and antimicrobial activity of Cr (III), Co (II) and Ni (II) complexes with 2-thiazoline-2-tiol derivative ligands against bacteria and yeasts of clinical importance
Keywords: 1,2-bis-bis (2-thiazolin-2-isulfanyl) ethane
Antimicrobial activity
Hidrotris (2-mercaptothiazolyl) borate
Issue Date: 2019
Publisher: Academia Brasileira de Ciências
Citation: HERRERA, K. M. S. et al. Synthesis, characterization and antimicrobial activity of Cr (III), Co (II) and Ni (II) complexes with 2-thiazoline-2-tiol derivative ligands against bacteria and yeasts of clinical importance. Anais da Academia Brasileira de Ciências, [S.l.], v. 91, n. 4, 2019.
Abstract: Four novel Cr (III), Co (II) and Ni (II) complexes with 2-thiazoline-2-tiol derivative ligands were synthesized and characterized using elemental, physiochemical, and spectroscopy analytical methods. The results showed the formation of ligands coordinated by sulfur atoms of the C = S bond to the L1 ligand and by the sulfur atom of the C-S bond and/or nitrogen of the intra C-ring bond of the L2 ligand. The activity of the complexes against Gram-negative, Gram-positive bacteria and yeasts of clinical importance was evaluated by broth microdilution method. The best result was obtained to L2-Ni compound against E. cloacae (Minimal Inhibitory Concentration (MIC) = 62.5 µg/mL). Additionally, the compounds showed anti-Candida activity (MIC values ranging from 250 to 500 µg/mL), except the L1-Cr that was not active against any tested microorganism.
URI: http://repositorio.ufla.br/jspui/handle/1/40825
Appears in Collections:DQI - Artigos publicados em periódicos



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