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metadata.artigo.dc.title: Functional models in genome-wide selection
metadata.artigo.dc.creator: Moura, Ernandes Guedes
Pamplona, Andrezza Kellen Alves
Balestre, Marcio
metadata.artigo.dc.subject: Sequencing technologies
Prediction of genomic values
Genomic analysis
Genomic selection
Genetic markers
Tecnologias de sequenciamento
Previsão Bayesiana de valores genéticos
Análise genômica
Seleção genômica
Marcadores genéticos
metadata.artigo.dc.publisher: National Center for Biotechnology Information Oct-2019
metadata.artigo.dc.identifier.citation: MOURA, E. G.; PAMPLONA, A. K. A.; BALESTRE, M. Functional models in genome-wide selection. Plos One, San Francisco, v. 14, n. 10, Oct. 2019. Paginação irregular.
metadata.artigo.dc.description.abstract: The development of sequencing technologies has enabled the discovery of markers that are abundantly distributed over the whole genome. Knowledge about the marker locations in reference genomes provides further insights in the search for causal regions and the prediction of genomic values. The present study proposes a Bayesian functional approach for incorporating the marker locations into genomic analysis using stochastic methods to search causal regions and predict genotypic values. For this, three scenarios were analyzed: F2 population with 300 individuals and three different heritability levels (0.2, 0.5, and 0.8), along with 12,150 SNP markers that were distributed through ten linkage groups; F∞ populations with 320 individuals and three different heritability levels (0.2, 0.5, and 0.8), along with 10,020 SNP markers that were distributed through ten linkage groups; and data related to Eucalyptus spp. to measure the model performance in a real LD setting, with 611 individuals whose phenotypes were simulated from QTLs distributed through a panel of 36,812 SNPs with known positions. The performance of the proposed method was compared with those of other genome selection models, namely, RR-BLUP, Bayes B and Bayesian Lasso. The Bayesian functional model presented higher or similar predictive ability when compared with those classical regressions methods in simulated and real scenarios on different LD structures. In general, the Bayesian functional model also achieved higher computational efficiency, using 12 SNPs per MCMC round. The model was efficient in the identification of causal regions and showed high flexibility of analysis, as it is easily adaptable to any genomic selection model.
metadata.artigo.dc.language: en_US
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