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metadata.artigo.dc.title: Exploring the structural and functional aspects of the phospholipase A2 from Naja spp
metadata.artigo.dc.creator: Trento, Marcus Vinícius Cardoso
Sales, Thais Aparecida
Abreu, Tatiane Silva de
Braga, Mariana Aparecida
Cesar, Pedro Henrique Souza
Marques, Tamara Rezende
Marcussi, Silvana
metadata.artigo.dc.subject: Snake venom toxins
Structural domains
Activity on membranes
metadata.artigo.dc.publisher: Elsevier Nov-2019
metadata.artigo.dc.identifier.citation: TRENTO, M. V. C. et al. Exploring the structural and functional aspects of the phospholipase A2 from Naja spp. International Journal of Biological Macromolecules, [S.l.], v. 140, p. 49-28, Nov. 2019.
metadata.artigo.dc.description.abstract: Naja spp. venom is a natural source of active compounds with therapeutic application potential. Phospholipase A2 (PLA2) is abundant in the venom of Naja spp. and can perform neurotoxicity, cytotoxicity, cardiotoxicity, and hematological disorders. The PLA2s from Naja spp. venoms are Asp 49 isoenzymes with the exception of PLA2 Cys 49 from Naja sagittifera. When looking at the functional aspects, the neurotoxicity occurs by PLA2 called β-toxins that have affinity for phosphatidylcholine in nerve endings and synaptosomes membranes, and by α-toxins that block the nicotinic acetylcholine receptors in the neuromuscular junctions. In addition, these neurotoxins may inhibit K+ and Ca++ channels or even interfere with the Na+/K+/ATPase enzyme. The disturbance in the membrane fluidity also results in inhibition of the release of acetylcholine. The PLA2 can act as anticoagulants or procoagulant. The cytotoxicity exerted by PLA2s result from changes in the cardiomyocyte membranes, triggering cardiac failure and hemolysis. The antibacterial activity, however, is the result of alterations that decrease the stability of the lipid bilayer. Thus, the understanding of the structural and functional aspects of PLA2s can contribute to studies on the toxic and therapeutic mechanisms involved in the envenomation by Naja spp. and in the treatment of pathologies.
metadata.artigo.dc.language: en_US
Appears in Collections:DQI - Artigos publicados em periódicos

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