Please use this identifier to cite or link to this item: http://repositorio.ufla.br/jspui/handle/1/41258
metadata.artigo.dc.title: Inflamm-aging: why older men are the most susceptible to SARS-CoV-2 complicated outcomes
metadata.artigo.dc.creator: Bonafè, Massimiliano
Prattichizzo, Francesco
Giuliani, Angelica
Storci, Gianluca
Sabbatinelli, Jacopo
Olivieri, Fabiola
metadata.artigo.dc.subject: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
COVID-19
Interleukin-6
Cardiovascular diseases
Inflamm-aging
Host-directed therapies
metadata.artigo.dc.publisher: Elsevier
metadata.artigo.dc.date.issued: 2020
metadata.artigo.dc.identifier.citation: BONAFÈ, M. et al. Inflamm-aging: why older men are the most susceptible to SARS-CoV-2 complicated outcomes. Cytokine & Growth Factor Reviews, [S.l.], 2020. No prelo.
metadata.artigo.dc.description.abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized by a high mortality of elderly men with age-related comorbidities. In most of these patients, uncontrolled local and systemic hyperinflammation induces severe and often lethal outcomes. The aging process is characterized by the gradual development of a chronic subclinical systemic inflammation (inflamm-aging) and by acquired immune system impairment (immune senescence). Here, we advance the hypothesis that four well-recognized features of aging contribute to the disproportionate SARS-CoV-2 mortality suffered by elderly men: i. the presence of subclinical systemic inflammation without overt disease, ii. a blunted acquired immune system and type I interferon response due to the chronic inflammation; iii. the downregulation of ACE2 (i.e. the SARS-CoV-2 receptor); and iv. accelerated biological aging. The high mortality rate of SARS-CoV-2 infection suggests that clarification of the mechanisms of inflamm-aging and immune senescence can help combat not only age-related disorders but also SARS-CoV-2 infection.
metadata.artigo.dc.identifier.uri: http://www.sciencedirect.com/science/article/pii/S1359610120300848
http://repositorio.ufla.br/jspui/handle/1/41258
metadata.artigo.dc.language: en_US
Appears in Collections:FCS - Artigos sobre Coronavirus Disease 2019 (COVID-19)

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